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Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer

Award Number: S10OD040199
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2026
PERIOD OF PERFORMANCE END DATE: 05/14/2027

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Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer - Project Summary/Abstract: We request funding through the NIH S10 Shared Instrumentation Grant program to acquire a LUMICKS Avidion Cell Avidity Analyzer, a transformative high-throughput platform designed to quantitatively measure cell-cell interaction avidity. Currently, our institution faces significant limitations in systematically assessing cellular avidity, a critical parameter predictive of efficacy in adoptive cellular immunotherapies such as chimeric antigen receptor (CAR) T-cell therapies. The proposed instrument addresses this gap, enabling simultaneous, high-throughput quantification of avidity across hundreds of experimental conditions, overcoming bottlenecks of existing low- throughput methods. The Avidion analyzer uniquely integrates advanced centrifugal force-based technology, multicolor fluorescence imaging, automated liquid handling, and robotic cartridge management. This combination provides unprecedented sensitivity, throughput, and specificity in measuring interactions between engineered immune cells and their targets. Our major and minor users propose projects leveraging this advanced capability to significantly accelerate discovery and clinical translation. Major user projects include: (1) Systematic CRISPR-based screening of adhesion and costimulatory molecules influencing immune synapse formation and CAR T functionality; (2) High-throughput quantification of anti-CD79 CAR T-cell avidity to predict in vivo efficacy in lymphoma models; (3) Development of peptide-centric CAR-T cells targeting KRAS G12V and other neoantigens in solid tumors; (4) Identification of resistance mechanisms in BCMA- targeted immunotherapies in multiple myeloma through avidity profiling; and (5) Characterization of T- cell avidity impairments caused by lipid-rich tumor microenvironments in ovarian cancer ascites. Minor users will utilize the instrument to optimize novel CAR constructs, synthetic adhesion molecules, and T- cell receptor-based therapies, addressing critical scientific and clinical questions across hematologic malignancies and solid tumors. Acquisition of the LUMICKS Avidion analyzer will significantly enhance NIH- funded translational research efforts, driving innovative therapies from bench to bedside, ultimately benefiting public health through improved patient outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $573,005 )
2026	2026	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	1	5/7/2026	NEW	$573,005
														Subtotal = $573,005

Grand Total All Awards = $573,005

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Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer

Award Number: S10OD040199

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2026

PERIOD OF PERFORMANCE END DATE: 05/14/2027

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