Enabling Anatomical, Functional, and Molecular Imaging by Upgrading a Vevo 3100 to Vevo F2-LAZR-X Ultrasound and Photoacoustic Scanner - PROJECT SUMMARY The objective of this application is to furnish investigators from the University of Rochester, University of Rochester Medical Center (URMC), and their collaborators with a state-of-the-art small animal imaging system, the Vevo F2 LAZR-X. This advanced instrument, known as a high-resolution multi-model Ultrasound and Photoacoustic Imaging System, offers the essential tools and resources to propel their interdisciplinary research forward. With its ability to conduct real-time in-vivo imaging in rodents, the system can also be used to study large animals. The University of Rochester boasts a robust portfolio of NIH-funded research programs and is the hub for a large group of NIH-funded investigators conducting pioneering studies and translational research across diverse research areas. These investigators represent many distinct departments associated with five core research centers or institutes, guided by a nationally recognized research team specializing in ultrasound and photoacoustic imaging. Currently, despite a significant research demand for access to small animal imaging facilities, the University of Rochester and URMC lacks a state-of-the-art photoacoustic imaging system for detailed anatomical, functional, physiological, and molecular imaging. The aim of this application is to procure the Vevo F2 LAZR-X ultrasound and photoacoustic imaging system that will enable investigators to undertake a wide spectrum of foundational and applied research projects. The principal investigator and the key contributors seek not just enhancement of new and ongoing research programs, but also to achieve greater understanding and appreciation of the underpinning science and technology. Introducing this distinctive and state of the art equipment to the University of Rochester will foster collaboration among researchers who bring complementary methodologies to the table. This will bolster advancements in both scientific and technological domains and enhance the development of our human resources. Acquiring and maintaining state-of-the-art imaging methodologies attracts the best and brightest, produces sought-after trainees with cutting edge training and marketable skills, and fosters the continuing success of our NIH-funded programs across multiple disciplines.