Purchase of an Image-Guided Small-Animal Irradiator - Project Summary/Abstract Washington University in St. Louis has a rich tradition of radiation research and is a world leader in the field of radiation oncology for clinical care, as well as physics and biological research. Over the past twenty years, much emphasis has been placed on the development of instrumentation for the non-invasive imaging of biological processes in small animals, thereby providing investigators with a better understanding of the biology and the potential of therapeutic interventions in preclinical models. In this regard, Washington University is a recognized leader, with outstanding programs and instrumentation for preclinical magnetic resonance, nuclear, and optical imaging. Preclinical photon irradiators that can deliver radiation to precise anatomical locations in small animals are an important component of these research efforts. We currently have an XStrahl small animal radiation research platform (SARRP) irradiator, however, it is nearing the end its useful lifetime and the technology is outdated. We therefore request funds to purchase a new, state-of-the-art Precision X-Ray SmART+ Biological Irradiator for small animal radiation delivery. We believe this irradiator is superior to the latest irradiator produced by Xstrahl. The state-of-the-art SmART+, is an image-guided, isocentric (360°rotation, with arc therapy capability), self-shielded research irradiator with integrated safety interlock system. It combines a high resolution (100 µm) cone-beam CT imaging system and a high-dose rate (up to approximately 6.5 Gy/min) therapeutic X- ray source into a single integrated, computer-controlled platform. It comes standard with a 4500W generator and has the highest degree of targeting accuracy 0.05mm about the isocenter. Research projects for seven major users with NIH funding and a critical need for the SmART+ are described, along with two minor users. The PI has managed the current small animal irradiator for the past eight years and has of expertise in preclinical radiation and cancer biology research. He has assembled a strong team to oversee operations and QA of the instrument. In addition, Washington University has made a significant institutional commitment to ensure the successful use of the device after its installation. The irradiator will allow investigators to study basic questions regarding radiation research in an in vivo, preclinical model that will eventually lead to new paradigms in the way we treat disease in the clinical setting.
