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Orbitrap Eclipse Tribrid Mass Spectrometer for Biomedical High end USERS

Award Number: S10OD034312
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2023
PERIOD OF PERFORMANCE END DATE: 09/14/2024

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Orbitrap Eclipse Tribrid Mass Spectrometer for Biomedical High end USERS - Project Abstract The goal of this proposal is to request funds to acquire a new Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer, with ETD, UVPD, FAIMS, and high mass range capabilities to enable cutting-edge protein analysis at the University of Alabama at Birmingham (UAB). The proposed instrumentation will significantly update in- house mass spectrometry (MS) technology located in the Biochemistry and Molecular Genetics Biomedical FT- MS Shared Resource Laboratory (SRL). The Biomedical FT-MS SRL is a MS-based shared research facility that provides the entire UAB research community, and others, with high resolution LC-MS methods for proteomics, glycoprotein analysis, protein biochemistry, and PTM characterization. The Biomedical FT-MS SRL has been serving UAB investigators and the community for more than 17 years. Currently, all experiments are conducted on a LTQ Orbitrap Velos Pro hybrid mass spectrometer with ETD that has been in service for 13 years. This is the only high-resolution instrument at UAB with ETD capabilities for direct assessment of protein glycosylation and other modifications. As a result, we consistently have samples running on the instrument 6 out of 7 days each week and are met with increasing demand to provide innovative and customized methods to support NIH- funded research. The requested instrumentation will exclusively provide the substantial technological upgrades needed to fill the gaps in our current capabilities, by expanding the ability to analyze heavily modified proteins, intact proteins and protein complexes such as (glycosylated) antibodies, and crosslinked proteins. These vital upgrades include maximum speed, sensitivity, mass accuracy and resolving power across essentially all bioanalytical and chemical applications to ensure accurate identification and monitoring of analytes. The Biomedical FT-MS SRL has the necessary physical and administrative infrastructure to support a new mass spectrometer, in addition to technical expertise and motivation to support new and current projects .Acquisition of the Orbitrap Eclipse Tribrid will also alleviate the burden of consistent maintenance and monitoring of the instrument, and free up the scientific personnel to perform other research duties. Implementing this new technology will transform the NIH-funded projects by providing UAB investigators with new tools to support their research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	000	1	2/11/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,687,401 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	000	1	9/12/2023	NEW	$1,687,401
														Subtotal = $1,687,401

Grand Total All Awards = $1,687,401

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Orbitrap Eclipse Tribrid Mass Spectrometer for Biomedical High end USERS

Award Number: S10OD034312

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2023

PERIOD OF PERFORMANCE END DATE: 09/14/2024

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