Thursday, January 8, 2026 1/8/2026

Upgrade of Bruker Time-domain EPR Spectrometer

Award Number: S10OD032355
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Upgrade of Bruker Time-domain EPR Spectrometer - This SIG (Shared Instrumentation Grant) project requests NIH funds for a major upgrade of an existing and fully functional Bruker Biospin time domain E580 electron paramagnetic resonance (EPR) spectrometer configured to operate at X- (9.5 GHz) and Q-band (34 GHz) resonance frequencies and acquired back in 2009. The proposed upgrade will significantly expand capabilities of the existing instrument for obtaining atomic-level details on the structural organization of catalytic metal centers in enzymes, free radical intermediates of biochemical and photosynthetic processes, and structural organization oligonucleotides, water soluble proteins, and membrane protein complexes. The specific components of the proposed upgrades include adding (1) pulse-shaping and frequency chirping capabilities enabled by AWG (arbitrary waveform generator) technology, (2) 300 W Q-band (34 GHz) amplifier to achieve a further - up to 5.5-fold - increase in the excitation bandwidth, and (3) cryogen-free variable temperature (5 K to 300 K) accessory to carry out these EPR experiments at optimal temperatures and eliminate dependence on a non-renewable liquid Helium which short supply is creating a major bottleneck in the research. The upgraded instrument will allow for carrying out time-domain EPR experiments at lower protein concentrations, increase the distance range and improve accuracy of longer-range distance constrains, and expand studies of protein systems and, particularly, membrane protein complexes, we have currently major difficulties with because of the equipment limitations. These capabilities will benefit a group if six Major and four Minor users from North Carolina State University and other collaborating groups in North and South Carolina and the USA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Research Infrastructure Programs	000	1	12/12/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Research Infrastructure Programs	000	1	7/3/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $599,903 )
2022	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Research Infrastructure Programs	000	1	7/18/2022	NEW	$599,903
														Subtotal = $599,903

Grand Total All Awards = $599,903

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Upgrade of Bruker Time-domain EPR Spectrometer

Award Number: S10OD032355

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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