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Enhancing Biomedical Research Infrastructure with a Spinning Disc Confocal Microscope at a Rural-Serving Medical Institution

Award Number: S10GM164845
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Enhancing Biomedical Research Infrastructure with a Spinning Disc Confocal Microscope at a Rural-Serving Medical Institution - This proposal requests funding to acquire a state-of-the-art Olympus IX85 Automated Inverted Microscope configured with Cicero Spinning Disc Confocal technology to support the biomedical research and educational missions at Sam Houston State University College of Osteopathic Medicine (SHSU-COM). This high-speed, high-resolution confocal imaging platform is essential for researchers investigating the molecular and cellular basis of neurodevelopment, cancer, reproductive biology, and toxicology using zebrafish models, human cell culture, and oocytes. The proposed instrument will directly support five active research programs: (1) dissecting the role of Selenophosphate Synthetase 1 (SEPHS1) in neural circuit formation and behavior through functional analysis of human alleles in zebrafish embryos; (2) developing EGFR-targeted nanoemulsions for treating metastatic colorectal cancer using xenografted zebrafish larvae; (3) characterizing the role of Integrin alpha 6 in zebrafish hindbrain neurovascular development; (4) evaluating endocrine-disrupting chemicals and their cytoskeletal and genotoxic effects in human granulosa cells and early embryos; and (5) enhancing biomedical education through hands-on microscopy training for medical and graduate students. The availability of this imaging system will significantly accelerate data acquisition, improve spatial and temporal resolution of live and fixed specimens, and enable multi-channel fluorescence imaging. This shared resource will support basic and translational biomedical research at SHSU-COM and strengthen educational training for students. Ultimately, this instrument will advance scientific discovery, support physician-scientist training, and enhance SHSU-COM’s capacity to contribute to the biomedical research enterprise.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,979 )
2026	2026	SAM HOUSTON STATE UNIVERSITY	1806 AVE J	HUNTSVILLE	TX	77341	WALKER	USA	Biomedical Research and Research Training	000	1	7/16/2026	NEW	$249,979
														Subtotal = $249,979

Grand Total All Awards = $249,979

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Enhancing Biomedical Research Infrastructure with a Spinning Disc Confocal Microscope at a Rural-Serving Medical Institution

Award Number: S10GM164845

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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