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Size Exclusion Chromatography-Multi Angle Light Scattering (SEC-MALS) for Enhancing Biomedical Research and Education at Fresno State

Award Number: S10GM164793
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Size Exclusion Chromatography-Multi Angle Light Scattering (SEC-MALS) for Enhancing Biomedical Research and Education at Fresno State - Project Summary/Abstract This proposal requests funding to acquire a size exclusion chromatography coupled with multi-angle light scattering (SEC-MALS) instrument to enhance biomedical research and educational capabilities at California State University, Fresno (Fresno State). Accurate determination of the molecular weight and size of macromolecules in their native states is essential to many areas of biomedical and biochemical research, but it remains technically challenging under the current research infrastructure at Fresno State. SEC-MALS is a powerful analytical technique that enables precise determination of molecular weight (molar mass) and size (radius of gyration) for a wide range of macromolecules in solution, including proteins, lipids, and nanoparticles. A key limitation of conventional analytical SEC is that it only provides relative molecular weights based on calibration standards. SEC-MALS instead delivers absolute molar mass with high accuracy and is widely used in biomedical research for applications such as protein characterization and pharmaceutical formulation. The requested instrument will support multiple research projects, including the design of multienzyme biocatalysts, antibody engineering for cancer imaging, and characterization of quantum dot assemblies, allowing these studies to advance beyond current technological limitations at Fresno State. The instrument will also be integrated into biochemistry and analytical chemistry laboratory courses to provide hands-on training in advanced molecular characterization to approximately 80 students each year. This activity will enhance the educational preparation of our students in the biomedical sciences by exposing them to analytical instrumentation commonly used in modern biomedical research. Fresno State is located in California’s Central Valley, with more than 80% of its students coming from the region. A core strategic goal of the university is to prepare the next generation of STEM and biomedical professionals through innovation and discovery. Acquisition of the SEC-MALS system will bring critical new research capabilities to our campus, strengthen faculty and student research, and expand opportunities for high-impact training in the biomedical sciences at Fresno State.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $250,000 )
2026	2026	CALIFORNIA STATE UNIVERSITY FRESNO	5150 N MAPLE AVE	FRESNO	CA	93740	FRESNO	USA	Biomedical Research and Research Training	000	1	8/10/2026	NEW	$250,000
														Subtotal = $250,000

Grand Total All Awards = $250,000

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Size Exclusion Chromatography-Multi Angle Light Scattering (SEC-MALS) for Enhancing Biomedical Research and Education at Fresno State

Award Number: S10GM164793

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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