Thursday, January 1, 2026 1/1/2026

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics

Award Number: RM1MH138313
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2029

Group Awards By:

View Award Description

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics - PROJECT SUMMARY/ABSTRACT In the past decade, significant progress has been made in identifying genetic variants associated with neurodevelopmental and psychiatric disorders like autism, schizophrenia, and intellectual disability. However, understanding how these genes affect brain function and contribute to disease remains a challenge due to the diverse experimental approaches used. To address this, we have assembled the Washington University Scalable Mouse Assay Center (WU-SMAC), an Assay and Data Generation Center (ADGC) for the SSPsyGene consortium. We will comprehensively investigate the impact of prioritized mutations known to cause neurodevelopmental and psychiatric disorders using over 100 mouse lines. Through a combination of behavioral analysis, anatomical mapping, and molecular assessments, our project seeks to uncover the molecular and spatial changes in the brain caused by these mutations and their subsequent effects on behavior. We will deeply assess the phenotype of each mutant using high-content, machine-learning driven behavioral analysis, automated home-cage monitoring of learning behavior and cognitive flexibility, and careful single nucleus & spatial transcriptomics. We will coordinate data serving and distribution with the other ADGCs and Data Resource and Administrative Coordination Center, and provide a unique mouse neuropsychiatric disease brain bank for the entire consortium to enable the replication of findings from other ADGC's systems within the complex milieu of a fully developed mammalian brain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,434,430 )
2026	2026	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	2	12/19/2025	NON-COMPETING CONTINUATION	$2,434,430
														Subtotal = $2,434,430

Issue Date FY: 2025 ( Subtotal = $2,462,651 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	001	1	6/11/2025	NEW	$0
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	1	11/25/2024	NEW	$2,462,651
														Subtotal = $2,462,651

Grand Total All Awards = $4,897,081

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics

Award Number: RM1MH138313

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer