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The Community Paramedic Response and Overdose Outreach with Wraparound Services (CROSSROADS) Study

Award Number: RM1DA064518
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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The Community Paramedic Response and Overdose Outreach with Wraparound Services (CROSSROADS) Study - ABSTRACT Overdose continues to be a leading cause of death in the US. People impacted by the criminal legal system (CLS) experience high rates of substance use and overdose. While recent investments have focused on treatment of people in jail and prisons, less work has examined how to deploy and optimize interventions at earlier points in the sequential intercept model to prevent adverse substance use outcomes. Community paramedic (CP) programs have launched nationally in response to the overdose epidemic. They are medically-trained first responders who respond via 911 after an overdose call. CPs provide life-saving intervention (e.g., naloxone), medications for opioid use disorder (MOUD), and linkage to health services, with follow-up after the initial encounter. Few CP programs incorporate connection to wraparound services. Therefore, we propose the Community Paramedic Response and Overdose Outreach with Services (CROSSROADS) Study, taking place in Durham, NC; Pittsburgh, PA; Miami, FL; and Portland, ME. Our aims are to: 1) Determine the core components of the proposed CROSSROADS intervention (CP program + wraparound services); 2) Compare the CROSSROADS intervention versus standard of care CP programs across the four sites on frequency of opioid and/or stimulant use, overdose events, and treatment engagement and linkage to care for substance use disorder; and 3) Identify the acceptability, appropriateness, penetration, and sustainability


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,536,230 )
2026	2026	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Drug Use and Addiction Research Programs	001	2	7/10/2026	NON-COMPETING CONTINUATION	$1,536,230
2026	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Drug Use and Addiction Research Programs	000	1	1/15/2026	NEW	$0
														Subtotal = $1,536,230

Issue Date FY: 2025 ( Subtotal = $1,653,005 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Drug Use and Addiction Research Programs	001	1	9/9/2025	NEW	$46,125
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Drug Use and Addiction Research Programs	000	1	8/28/2025	NEW	$1,606,880
														Subtotal = $1,653,005

Grand Total All Awards = $3,189,235

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The Community Paramedic Response and Overdose Outreach with Wraparound Services (CROSSROADS) Study

Award Number: RM1DA064518

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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