Neuroscience has an essential requirement for large-scale imaging and perturbation tools.
Such tools would be transformative in the mapping of brain function and the diagnosis and
treatment of neurological disorders. The proposed project is aimed at uncovering regulation of
glymphatic and vascular flow in the progression of Alzheimer’s disease (AD) at whole-brain,
cellular-resolution scales using novel whole-brain imaging modalities. Our project’s goal is to use
state-of-the-art in vivo imaging techniques to study cerebrospinal fluid (CSF) flow in the brain, and
how this flow interacts with AD-related protein accumulation in transgenic models. We will study
how flow in this system is perturbed in AD, with a focus on clearance of waste products