Tuesday, September 26, 2023 9/26/2023

High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin Supplement

Award Number: RF1NS126102
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT Neuroscience has an essential requirement for large-scale imaging and perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering regulation of glymphatic and vascular flow in the progression of Alzheimer’s disease (AD) at whole-brain, cellular-resolution scales using novel whole-brain imaging modalities. Our project’s goal is to use state-of-the-art in vivo imaging techniques to study cerebrospinal fluid (CSF) flow in the brain, and how this flow interacts with AD-related protein accumulation in transgenic models. We will study how flow in this system is perturbed in AD, with a focus on clearance of waste products


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $423,750 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/21/2023	SUPPLEMENT FOR EXPANSION	$423,750


Issue Date FY: 2022 ( Subtotal = $2,525,614 )
2022	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/16/2022	NEW	$2,525,614


Grand Total All Awards = $2,949,364

Sum of Action Amount is $2,949,364;

Grand Total = $2,949,364

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High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin Supplement

Award Number: RF1NS126102

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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