Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Diversity Supplement: Effects of stimulation on resilience in brain immune cells

Award Number: RF1NS109226
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2026

Group Awards By:

View Award Description

Diversity Supplement: Effects of stimulation on resilience in brain immune cells - Gamma Sensory Flicker as an Early Intervention for Alzheimer's Disease: Mechanisms and Protective Effects Alzheimer's disease (AD) requires a new therapeutic approach to intervene prior to or early in the disease. In the previous funding period, the PI and team discovered that gamma, or 40Hz, sensory flicker (lights and sounds turning on and off with millisecond precision) has beneficial effects in mouse models of Alzheimer's pathology at symptomatic stages. Gamma flicker drove gamma neural activity, reduced amyloid plaques, recruited microglia to engulf amyloid beta (Aβ), and restored memory behavior in mice with Aβ pathology. This proposal marks the exciting shift of this research to intervene in AD during the preclinical stages prior to plaque accumulation and the onset of memory deficits. Microglia and cytokines play a disease modifying role in AD and affect network function, with potential damaging or beneficial effects. Recent research, from our team and others, reveals protective immune gene and protein signatures in early AD pathogenesis. The goal of this proposal is to determine how flicker stimulation affects protective immune function in preclinical AD stages to improve neural signatures of memory and to elucidate the mechanisms of these effects. Using cutting edge transcriptomic and proteomic analyses and large-scale neural recordings, we will determine the effects of flicker on microglia phenotypes and neural signatures of memory. Using pharmacological and genetic manipulations, we will determine the causal role of microglia and microglial signaling in mediating flicker's effects on microglia phenotype and network function. We will determine if flicker-induced microglia gene transcription overlaps with recently defined human anti-inflammatory microglia markers present in early AD, using our teams' discoveries from cutting edge cell-type specific analysis of human tissue. Aim 1 will define the effects of flicker on microglia phenotype at preclinical stages, the molecular mechanisms involved, and the human-relevant transcriptional effects. Aim 2 will establish how preclinical flicker affects neural signature of memory integration during learning and the causal role of microglia in this process. This research will result in a paradigm shift to use noninvasive brain stimulation prophylactically in people at risk of AD prior to plaques or symptoms. Furthermore, this research will reveal new mechanisms by which flicker stimulation promotes protective immune function and promotes memory.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $376,571 )
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	9/17/2024	SUPPLEMENT FOR EXPANSION	$187,815
2024	2023	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	1/4/2024	COMPETING CONTINUATION	$188,756
														Subtotal = $376,571

Issue Date FY: 2023 ( Subtotal = $1,967,115 )
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	9/21/2023	COMPETING CONTINUATION	$1,967,115
														Subtotal = $1,967,115

Grand Total All Awards = $2,343,686

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Diversity Supplement: Effects of stimulation on resilience in brain immune cells

Award Number: RF1NS109226

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer