Wednesday, October 1, 2025 10/1/2025

Hypothalamic Pathways of Age Related Homeostatic Dysregulation

Award Number: RF1AG091203
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Hypothalamic Pathways of Age Related Homeostatic Dysregulation - PROJECT SUMMARY This project is designed to determine the role of hypothalamic neurons in the progression of physiological decline with age. During summer heat waves, older adults are extremely vulnerable to hyperthermia and dehydration leading to higher risk of morbidity and mortality. Understanding the cellular mechanisms responsible for increased frailty with age is critical for improving heathspan in older adults. The goal of this proposal is to establish a novel role for supraoptic hypothalamic neurons in causing age-dependent physiological disturbances which disrupt neuroendocrine homeostasis. Guided by our recent finding that arginine-vasopressin (Avp) transcription in supraoptic hypothalamic neurons is dramatically increased in aged mice, the proposed experiments leverage state-of-the-art methods for monitoring and manipulating vasopressin neurons in mice with the goal to elucidate their role in thermoregulation and fluid balance. This proposal will also explore the role of brain inflammation in altering physiological homeostasis through dysregulation of vasopressin neuronal function. Finally, the therapeutic potential of gene therapies focusing on vasopressin neurons will be investigated in the context of behavioral and physiological frailty with age. The proposed studies will lay the groundwork for imputing a causal role of supraoptic vasopressin neurons in the onset of age-dependent frailty.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,591,620 )
2025	2025	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Aging Research	000	1	9/11/2025	NEW	$2,591,620
														Subtotal = $2,591,620

Grand Total All Awards = $2,591,620

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Hypothalamic Pathways of Age Related Homeostatic Dysregulation

Award Number: RF1AG091203

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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