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Facilitate Observational Studies of Alzheimer's Disease and Alzheimer's Disease-Related Dementias Using Ontology and Natural Language Processing

Award Number: RF1AG072799
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Facilitate Observational Studies of Alzheimer's Disease and Alzheimer's Disease-Related Dementias Using Ontology and Natural Language Processing - PROJECT SUMMARY As the 6th leading cause of death in the US, Alzheimer's disease (AD) and Alzheimer's disease- related dementias (ADRD) affect about 5.7 million Americans. However, up until now, our understanding of risk factors of AD/ADRD is still limited and our efforts on developing effective treatments for AD/ADRD have been greatly disappointing. Therefore, there is an urgent need to develop new methods to conduct AD/ADRD research more efficiently. One of the potential approaches is to leverage large, longitudinal, observational clinical data accumulated in electronic health records (EHRs). Nevertheless, current uses of EHRs for AD/ADRD research is very limited, often requiring manual data extraction and normalization (i.e., manual chart review), which is labor-intensive and time-consuming. Therefore, in this study, we plan to develop novel ontology and natural language processing (NLP) based informatics methods and tools to automatically extract and normalize AD/ADRD-related clinical data in EHRs, thus facilitating efficient AD/ADRD observational studies using EHRs. We propose the following three specific aims to achieve this goal: 1) Build an information model for EHR-based AD/ADRD research using a formal ontology representation approach; and 2) Extract and normalize AD/ADRD information in clinical documents using NLP technologies; and 3) Evaluate developed informatics methods and tools through demonstration studies and disseminate them to support observational AD/ADRD research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Aging Research	001	2	11/3/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,230,213
2024	2021	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Aging Research	002	2	3/14/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2021	UNIVERSITY OF HEALTH SCIENCE CENTER	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Aging Research	000	1	11/2/2023	NEW	-$1,230,213
2024	2021	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Aging Research	004	2	4/10/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,110
2024	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	003	1	4/10/2024	NEW	-$3,110
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,371,994 )
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON, THE	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Aging Research	001	1	6/7/2021	NEW	$0
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON, THE	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Aging Research	000	1	4/29/2021	NEW	$2,371,994
														Subtotal = $2,371,994

Grand Total All Awards = $2,371,994

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Facilitate Observational Studies of Alzheimer's Disease and Alzheimer's Disease-Related Dementias Using Ontology and Natural Language Processing

Award Number: RF1AG072799

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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