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PROMIS Profile Measures for Older Adults with Cognitive Impairment-Developing Versions for Older Adults with Cognitive Impairment and for Proxy Completion

Award Number: RF1AG059651
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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PROMIS Profile Measures for Older Adults with Cognitive Impairment-Developing Versions for Older Adults with Cognitive Impairment and for Proxy Completion - Project Summary The National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS®) was developed to provide precise and valid measures of patient-reported outcomes, establish a common metric across chronic health conditions, and enable computerized adaptive testing. Most patient-reported measures including PROMIS measures were not widely tested in the older adult population nor among those with Mild Cognitive Impairment (MCI) and Alzheimer’s Disease and Related Dementias (ADRD). Our previous study examined the reliability and validity of the PROMIS Profile measures in older adults, identified thresholds where cognitive impairment invalidates the use of these measures, and uncovered problematic items in this population. This renewal extends our previous work to 1) develop and validate a modified version of the PROMIS Profile measures suitable for older adults with cognitive impairment (OACI) and 2) develop adult proxy measures for patients unable to respond reliably (even with modification for cognitive impairment; Proxy-OACI).Cognitive interviews with 20 patients with low cognition (Montreal Cognitive Assessment ≤25) and 20 proxies are used to assess these new versions. Validation testing will be performed to show 1) the new PROMIS Profile-OACI is reliable at a lower MoCA/MMSE score than the original version, and 2) reliability of the new PROMIS Profile-Proxy OACI. The new measures will be tested in 250 patients and 200 proxies enrolled from outpatient practices with a range of cognitive impairment from MCI to ADRD and further validated and linked to PROMIS scale metrics using a sample of 500 adults from an internet panel of patients aged 65+. Scale reliability and item functioning will be assessed by investigating differential item functioning on the new PROMIS Profiles (using Item-Response Theory modeling). Validity will be assessed by examining the consistency of relationships between PROMIS Profiles and other variables (e.g., self and proxy reports on similar measures and measures of observable performance) cross- sectionally for concurrent validity. This study will result in improved PROMIS Profile measures of disability, mental health, and social engagement, with greater reliability and validity for older adults with cognitive impairment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $3,284,905 )
2026	2026	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Aging Research	000	6	4/29/2026	COMPETING CONTINUATION	$3,284,905
														Subtotal = $3,284,905

Grand Total All Awards = $3,284,905

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PROMIS Profile Measures for Older Adults with Cognitive Impairment-Developing Versions for Older Adults with Cognitive Impairment and for Proxy Completion

Award Number: RF1AG059651

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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