Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologies

Award Number: RC2DK135492
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2028

Group Awards By:

View Award Description

Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologies - PROJECT SUMMARY As a critical barrier tissue, the intestinal mucosa must balance complex environmental stimuli — including dietary components, microbes, metabolites, and xenobiotics — to fine-tune immune development and tolerance. In health, homeostasis is maintained via a constellation of specialized cell types that connect host physiology to these external signals. Disruption of intestinal physiology results in numerous diseases, including inflammatory conditions such as Crohn’s disease and ulcerative colitis. Here, we propose a framework to dissect the cellular mechanisms underlying the homeostatic and inflamed states in the small intestine and colon at unprecedented spatial and temporal resolution. In Aim 1, we will spatially profile gene and protein expression across human gut samples in health and disease, developing the necessary computational tools to identify critical disruptions in cell-cell communication networks that result from inflammation. Computational tools developed in this context will have broad application in studying tissue biology. Additionally, we will make cross-disease comparisons (e.g., Crohn’s disease, celiac disease, and eosinophilic gastroenteritis) to identify common inflammatory mechanisms independent of tissue type. In Aim 2, we will leverage experimental mouse models to spatially profile the dynamics of inflammation (from homeostasis through induction and resolution of inflammation) and dietary stress in the mouse gut — generating temporally resolved maps of these processes. In Aim 3, we will use organoid and cell-cell coculture models to determine how chemosensory pathways are translated into the coordinated cellular responses that maintain homeostasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,010,473 )
2026	2026	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/26/2026	NON-COMPETING CONTINUATION	$2,010,473
														Subtotal = $2,010,473

Issue Date FY: 2025 ( Subtotal = $2,017,193 )
2025	2025	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/25/2025	NON-COMPETING CONTINUATION	$2,017,193
														Subtotal = $2,017,193

Issue Date FY: 2024 ( Subtotal = $1,892,806 )
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/10/2024	NON-COMPETING CONTINUATION	$1,892,806
														Subtotal = $1,892,806

Issue Date FY: 2023 ( Subtotal = $2,024,973 )
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/27/2023	NEW	$2,024,973
														Subtotal = $2,024,973

Grand Total All Awards = $7,945,445

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologies

Award Number: RC2DK135492

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer