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Investigating Human Adipocyte Heterogeneity

Award Number: RC2DK116691
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/23/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2028

Group Awards By:

View Award Description

Investigating Human Adipocyte Heterogeneity - ABSTRACT The parenchymal cell of adipose tissue is the white adipocyte, which is now understood to be a dynamic and active participant in metabolic homeostasis. Adipocytes store and release energy as needed, they coordinate physiological functions throughout the body via the elaboration of “adipokines”, and they have associations with human disease traits. Understanding the diversity of human adipocytes has been challenging, because of the technical difficulties inherent in working with large, fragile cells. We have now used advanced single nuclear sequencing techniques to circumvent this issue, and have now identified seven distinct subpopulations of human white adipocytes. There are many questions remaining, including whether there are more subpopulations in different adipose depots, what their functions are, and how they develop. In this proposal we will address these issues using a combination of phenotyping modalities, combined with experimental manipulations of signaling molecules and transcription factors that are predicted to affect adipocyte subpopulation development and function. Furthermore, we will associate these subpopulations with human metabolic disease traits. Finally, a key deliverable of this proposal is a Human Adipose Tissue Knowledge Portal, which will assimilate the data generated here and integrate it with data from other groups, facilitating standardization of experimental protocols, data analysis, and nomenclature. The resulting database will be a community resource and the starting point for a new era of adipose tissue biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,149,635 )
2026	2026	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	5/6/2026	NON-COMPETING CONTINUATION	$0
2026	2026	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	4/9/2026	NON-COMPETING CONTINUATION	$2,149,635
														Subtotal = $2,149,635

Issue Date FY: 2025 ( Subtotal = $2,149,635 )
2025	2025	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	4/17/2025	NON-COMPETING CONTINUATION	$2,149,635
														Subtotal = $2,149,635

Issue Date FY: 2024 ( Subtotal = $2,111,451 )
2024	2024	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	5/23/2024	NON-COMPETING CONTINUATION	$2,111,451
2024	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	5/21/2024	COMPETING CONTINUATION	$914,756
2024	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	5/21/2024	NON-COMPETING CONTINUATION	-$914,756
														Subtotal = $2,111,451

Issue Date FY: 2023 ( Subtotal = $2,235,879 )
2023	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	5/24/2023	COMPETING CONTINUATION	$2,235,879
														Subtotal = $2,235,879

Issue Date FY: 2022 ( Subtotal = $1,682,774 )
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	4/12/2022	NON-COMPETING CONTINUATION	$1,682,774
														Subtotal = $1,682,774

Issue Date FY: 2021 ( Subtotal = $1,991,293 )
2021	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	3/12/2021	NON-COMPETING CONTINUATION	$1,991,293
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	3/10/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,991,293

Issue Date FY: 2020 ( Subtotal = $1,992,279 )
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/8/2020	NON-COMPETING CONTINUATION	$1,724,879
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	7/13/2020	SUPPLEMENT FOR EXPANSION	$267,400
														Subtotal = $1,992,279

Issue Date FY: 2019 ( Subtotal = $1,741,902 )
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	4/3/2019	NON-COMPETING CONTINUATION	$1,741,902
														Subtotal = $1,741,902

Issue Date FY: 2018 ( Subtotal = $1,783,808 )
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	4/23/2018	NEW	$1,876,449
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	6/1/2018	NEW	-$92,641
														Subtotal = $1,783,808

Grand Total All Awards = $17,838,656

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Investigating Human Adipocyte Heterogeneity

Award Number: RC2DK116691

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/23/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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