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A Rapid and Inexpensive Point-of-Care Test for Beta-Thalassemia Carriers

Award Number: R61HL154094
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2022

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A Rapid and Inexpensive Point-of-Care Test for Beta-Thalassemia Carriers - PROJECT SUMMARY/ABSTRACT This proposal describes the development of HemoTypeBT, a rapid and inexpensive point-of-care immunoassay test kit for the identification of beta-thalassemia carriers. Screening and counseling programs aimed at carriers have proven effective in reducing the incidence of this genetic disease by >90%. However, the cost and logistical burden of today's testing methods is a high barrier to implementation of such programs. The proposed test kit will be a lateral flow immunoassay, similar in principle to a home pregnancy test, and based on the highly successful HemoTypeSC test for sickle-cell disease. The test design is based on monoclonal antibodies (MAbs) specific for the small differences between disease-linked hemoglobin variants. At the successful conclusion of the proposed work, the HemoTypeBT test kit will be pre-clinically validated and ready for manufacturing and submission for approval to regulatory agencies worldwide.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	SILVER LAKE RESEARCH CORPORATION	1300 W OPTICAL DR	IRWINDALE	CA	91702	LOS ANGELES	USA	Blood Diseases and Resources Research	000	2	12/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	SILVER LAKE RESEARCH CORPORATION	1300 WEST OPTICAL DR STE 300	AZUSA	CA	91702	LOS ANGELES	USA	Blood Diseases and Resources Research	001	2	4/26/2022	NON-COMPETING CONTINUATION	$0
2022	2021	SILVER LAKE RESEARCH CORPORATION	1300 WEST OPTICAL DR STE 300	AZUSA	CA	91702	LOS ANGELES	USA	Blood Diseases and Resources Research	000	2	3/11/2022	NON-COMPETING CONTINUATION	$0
2022	2021	SILVER LAKE RESEARCH CORPORATION	1300 WEST OPTICAL DR STE 300	AZUSA	CA	91702	LOS ANGELES	USA	Blood Diseases and Resources Research	002	2	5/3/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $345,189 )
2021	2021	SILVER LAKE RESEARCH CORPORATION	1300 WEST OPTICAL DR STE 300	AZUSA	CA	91702	LOS ANGELES	USA	Blood Diseases and Resources Research	000	2	9/20/2021	NON-COMPETING CONTINUATION	$345,189
														Subtotal = $345,189

Issue Date FY: 2020 ( Subtotal = $348,500 )
2020	2020	SILVER LAKE RESEARCH CORPORATION	1300 WEST OPTICAL DR STE 300	AZUSA	CA	91702	LOS ANGELES	USA	Blood Diseases and Resources Research	000	1	8/10/2020	NEW	$348,500
														Subtotal = $348,500

Grand Total All Awards = $693,689

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A Rapid and Inexpensive Point-of-Care Test for Beta-Thalassemia Carriers

Award Number: R61HL154094

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2022

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