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Glucose Transporter Regulation in Obesity and Diabetes

Award Number: R56DK043051
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/1992
PERIOD OF PERFORMANCE END DATE: 03/31/2023

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Glucose Transporter Regulation in Obesity and Diabetes - Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Bridge Funding for DK43051– PI: Barbara B. Kahn, MD Long-term Overall Goal: To determine the mechanisms by which reduction of ChREBP in adipocytes causes systemic insulin resistance and impaired glucose transport in adipocytes. Background: Carbohydrate Response Element Binding Protein (ChREBP) is the major transcription factor regulating de novo lipogenesis (DNL, fatty acid synthesis from glucose) in adipocytes. We showed that adipose-selective ChREBP KO (AdChREBP KO) causes systemic insulin resistance and impairs insulin-stimulated glucose transport in adipocytes. In humans, expression of ChREBP and genes regulating DNL in adipose tissue correlate highly with insulin sensitivity measured by clamp. Specific Aims for One Year: Specific Aim 1: To maintain lab staff Specific Aim 2: To maintain mouse lines Specific Aim 3: To generate additional preliminary data


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	29	12/14/2023	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $172,900 )
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	29	3/21/2022	COMPETING CONTINUATION	$172,900
														Subtotal = $172,900

Grand Total All Awards = $172,900

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Glucose Transporter Regulation in Obesity and Diabetes

Award Number: R56DK043051

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/1992

PERIOD OF PERFORMANCE END DATE: 03/31/2023

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