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Effect of RCR healing on degenerative shoulder changes and 5y clinical outcomes

Award Number: R56AR083376
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Effect of RCR healing on degenerative shoulder changes and 5y clinical outcomes - Project Summary—Abstract Healing following rotator cuff repair (RCR) remains a significant clinical challenge. While most patients report improvements in clinical outcomes, approximately 20-30% experience a retear by 6 months. Failure of RCR healing can lead to significant clinical consequences, initiating a pathologic progression associated with worsening pain, function, and strength, and an increased risk of re-operation over time in some patients. However critical knowledge gaps persist in our understanding of the significance of RCR healing, the roles of other patient and surgical factors, and development of degenerative changes in determining longer-term clinical outcomes. Our proposal addresses these gaps by leveraging two ongoing prospective RCR cohorts of 161 patients being followed at our institution to collect comprehensive, and in some instances, first-of-kind data on shoulder pain and function, RCR healing, and associated degenerative shoulder pathology over 5 years following RCR. Aim 1 will measure and describe the evolution of clinical outcomes and degenerative changes over 5y following RCR using traditional and novel potentially more sensitive variables. Aim 2 will estimate the prognostic effect of 1y RCR healing status on clinical outcomes and on the evolution of degenerative shoulder pathology over 5y following RCR. Aim 3 will develop and provide online calculators for preoperative clinical prediction of 5y ASES score under alternative healing scenarios. The unique collection of longitudinal data on RCR healing and joint pathology in combination with clinical outcomes will offer valuable insights into the progression and severity of declining clinical and pathologic outcomes after RCR. This will enhance our understanding of the benefits of successful RCR healing and guide clinical decisions regarding targeted strategies to improve RCR healing. The online calculators would have immediate clinical impact by helping to identify and appropriately manage patients at risk for poor longer-term outcomes, thus facilitating the use of strategies to improve healing where needed.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	11/19/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $293,811 )
2024	2024	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/19/2024	NEW	$293,811
														Subtotal = $293,811

Grand Total All Awards = $293,811

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Effect of RCR healing on degenerative shoulder changes and 5y clinical outcomes

Award Number: R56AR083376

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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