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Delayed Anaphylaxis to Mammalian Meat caused by IgE Ab to alpha-gal

Award Number: R56AI113095
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/18/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2016

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Delayed Anaphylaxis to Mammalian Meat caused by IgE Ab to alpha-gal - DESCRIPTION (provided by applicant): Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated with two distinct forms of anaphylaxis: i) immediate onset anaphylaxis during first exposure to intravenous cetuximab, and ii) delayed onset anaphylaxis 3-6 hours after ingestion of mammalian food products (e.g., beef and pork). The overarching hypothesis for this proposal is that defining both the cause and the mechanism of the IgE Ab response to alpha-gal as well as identifying the antigen responsible for the delayed food reactions will provide insight into the factors that govern allergic responses and control anaphylaxis. The significance of investigating these reactions comes not only from the obvious importance of understanding a novel life threatening form of food allergy, but also because of the possibility of defining a totally new mechanism for reactions related to an important food substance. Our plan of research focuses on the epidemiology of IgE Ab to alpha-gal, the antigen that appears in the bloodstream 3-5 hours after eating beef, pork or lamb, and the role of tick bites in initiating the IgE response. Our current work has shown that IgE to the carbohydrate alpha-gal is present in a cohort of patients who report delayed anaphylaxis and allergic reactions after eating mammalian meat. We believe that IgE to alpha-gal represents a novel cause of food allergy. The specific aims outlined in this proposal are designed to investigate the epidemiology of this carbohydrate-directed IgE (Specific Aim #1), elucidate the mechanism for delayed reactions (Specific Aim #1), establish the cause of the IgE response (Specific Aim #2), and investigate the mechanism of specific IgE production against a glycan (Specific Aim #2). Overall, these studies are uniquely positioned to provide insight into a recently recognized allergic response as well as identify the molecules present during an allergic reaction and possibly establish a model for ecto-parasitic tick bites initiating an IgE response.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$1,176 )
2017	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	12/21/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,176
														Subtotal = -$1,176

Issue Date FY: 2016 ( Subtotal = -$3,931 )
2016	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	4/15/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$99,592
2016	2014	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	1	4/15/2016	NEW	-$103,523
														Subtotal = -$3,931

Issue Date FY: 2014 ( Subtotal = $393,523 )
2014	2014	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	1	7/18/2014	NEW	$393,523
														Subtotal = $393,523

Grand Total All Awards = $388,416

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Delayed Anaphylaxis to Mammalian Meat caused by IgE Ab to alpha-gal

Award Number: R56AI113095

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/18/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2016

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