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PD-L1 Signaling in Phagosomes

Award Number: R56AI071116
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2008
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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PD-L1 Signaling in Phagosomes - Host defense against microbial infection and pathology relies on immune responses that are activated by host receptors that recognize diverse microbial components and opsonins. Over the last 20 years remarkable progress has been made in developing this principle, and the body of literature documenting how receptors such as Toll-like receptors and C-type lectin receptors function is a testament to this progress. In this project, we are investigating how the process of phagocytosis by cells such as macrophages is a mechanism of innate sensing. Specifically, we have recently found that degradation of yeast in macrophage phagosomes reveals novel ligands for receptors including PD-L1. In this project, we will explore how this binding occurs and the identities of the ligand or ligands that are recognized.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $300,000 )
2025	2025	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	15	9/2/2025	COMPETING CONTINUATION	$300,000
														Subtotal = $300,000

Grand Total All Awards = $300,000

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PD-L1 Signaling in Phagosomes

Award Number: R56AI071116

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2008

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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