Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Estrogenic modulation of neural circuits that control temperature

Award Number: R56AG066821
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2027

Group Awards By:

View Award Description

Estrogenic modulation of neural circuits that control temperature - PROJECT SUMMARY The overall goal of this competitive renewal is to understand how changes in estrogen signaling alter thermoregulation. We hypothesize that the primary thermoregulatory role of estrogens is to promote temperature stability by coordinating responses across tissues, brain regions, and neuron populations. To test this hypothesis, we propose to dissect how estrogens coordinate the activity of neural circuits that control body temperature and how they affect the stability of body temperature around the thermal neutral points and responses to thermal challenge. This work provides a novel framing to understand hot flushes as symptoms of the broadly destabilizing effects of estrogen variability and withdrawal that coincide with the menopausal transition.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $382,473 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Aging Research	000	6	5/19/2026	COMPETING CONTINUATION	$382,473
														Subtotal = $382,473

Grand Total All Awards = $382,473

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Estrogenic modulation of neural circuits that control temperature

Award Number: R56AG066821

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer