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Pediatric brain tumors: Improving survival through integration of clinical molecular diagnostics and biologically targeted therapies into clinical trials

Award Number: R50CA275857
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/21/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Pediatric brain tumors: Improving survival through integration of clinical molecular diagnostics and biologically targeted therapies into clinical trials - PROJECT SUMMARY/ABSTRACT: Tumors of the central nervous system (CNS) are the leading cause of cancer death in children. Many of those who do survive suffer from significant lifelong morbidity due to toxicity of therapy. There is an urgent need to improve survival and decrease toxicity of therapy in children with brain tumors. My research focus is to improve survival for children with CNS tumors through the development of novel therapeutics and clinical trials based on biologic insights into the molecular drivers of disease. I conduct my research through collaborative studies that are made possible by the National Clinical Trials Network (NCTN), specifically the Children’s Oncology Group (COG). Nationally, I serve in a leadership role as the clinical vice-chair of the COG CNS committee, COG representative to the NIH Brain Malignancies Steering Committee (BMSC), and CNS representative to the Agent Prioritization Committee (APC) of the NIH-funded Pediatric Early Phase Clinical Trials Network (PEP-CTN). I have also recently led the creation of a data-sharing initiative called the INSPiRE consortium which aims to facilitate clinical trials and genomic data sharing between the COG and other international clinical trials consortia and registries. Locally, I serve as the Seattle Children’s Hospital site PI for COG, Medical Director of Clinical Research for the Seattle Children’s Ben Towne Center for Childhood Cancer Research, Principal Investigator of the Seattle Children’s Tumor Banking and Biology Study, and Medical Director of the Pediatric Brain Tumor Program. These complementary national and local roles allow me to provide support to a wide range of translational and clinical research efforts, providing access to all phases of research to children in Seattle and translating research discovery in Seattle to children across the world through the development of collaborative clinical trials. The opportunities afforded by this award would allow me to devote significant time to accelerate the development of high-impact clinical trials and to support critical efforts to improve molecular and clinical data sharing and local access to trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $175,338 )
2025	2025	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cancer Detection and Diagnosis Research	000	3	3/13/2025	NON-COMPETING CONTINUATION	$175,338
														Subtotal = $175,338

Issue Date FY: 2024 ( Subtotal = $175,338 )
2024	2024	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cancer Detection and Diagnosis Research	000	2	2/29/2024	NON-COMPETING CONTINUATION	$175,338
														Subtotal = $175,338

Issue Date FY: 2023 ( Subtotal = $175,338 )
2023	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cancer Detection and Diagnosis Research	000	1	3/21/2023	NEW	$175,338
														Subtotal = $175,338

Grand Total All Awards = $526,014

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Pediatric brain tumors: Improving survival through integration of clinical molecular diagnostics and biologically targeted therapies into clinical trials

Award Number: R50CA275857

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/21/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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