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Populating MPS database with data from multi-organ, human-on-a-chip microphysiological systems

Award Number: R44TR001326
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract: As stated in the Notice of Special Interest announcement, there is a need to populate the recently established MPS database with existing data generated by organ-on-a-chip systems. Having a centralized, public database with data from all available MPS systems will accelerate development and acceptance of the technology ultimately bringing better therapies to patients faster while significantly reducing the need for animal testing in drug discovery. In this proposal, we will compile data collected and published using Hesperos’ Human-on-a-Chip¿ microphysiological system (MPS), including data collected as part of the parent grant, and populate the MPS Database. Additionally, we will generate an internal structure that will facilitate compilation and submission of future data to the database. This will be especially valuable data to include as Hesperos’ multi-organ platform is among the worlds’ most advanced human-based in vitro platforms with several distinct innovations. First, the system uses a patented, pumpless mechanism to recirculate a customizable, serum-free medium using gravity to obtain bidirectional flow (while also having the capability for unidirectional flow when required). Second, the system is highly flexible with standard systems containing up to 5-organ or barrier tissues depending on the application of interest. This enables the ability to determine the efficacy and off-target toxic effects of both single drug treatments and drug-drug combinations, all in the same system. Lastly, the platform is equipped with bio-electromechanical devices that non-invasively monitor the functional changes to organs as compounds are introduced, metabolized, and excreted. These devices measure both the electrical (MEA’s) and mechanical (cantilevers to measure force) changes to organ-specific physiology for cardiac, skeletal muscle, neuronal tissues, and other organs producing an evaluation of the real-time functional changes of organs in response to treatment. Because our readouts focus on function that is analogous to clinical evaluations and not changes in cell viability, real time clinical correlations can be established using our PKPD models. This capability enables evaluation of both the acute and chronic effects of a therapeutic on the human body. For this effort, Hesperos will first establish data format requirements and conversion procedures necessary to produce the optimal data structure for the database. We will then convert existing, published data into the determined format and upload the information to the MPS Database.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	HESPEROS, INC.	12501 RESEARCH PKWY STE 100	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	000	5	4/5/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $77,997 )
2021	2021	HESPEROS, INC.	12501 RESEARCH PKWY STE 100	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	000	5	9/3/2021	SUPPLEMENT FOR EXPANSION	$77,997
														Subtotal = $77,997

Issue Date FY: 2020 ( Subtotal = $1,477,994 )
2020	2020	HESPEROS, INC.	12501 RESEARCH PKWY STE 100	ORLANDO	FL	32826	ORANGE	USA	Trans-NIH Research Support	000	4	12/31/2019	SUPPLEMENT FOR EXPANSION	$73,535
2020	2020	HESPEROS, INC.	12501 RESEARCH PKWY STE 100	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	002	5	9/1/2020	NON-COMPETING CONTINUATION	$1,404,459
2020	2017	HESPEROS, INC.	12501 RESEARCH PKWY STE 100	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	001	2	3/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,477,994

Issue Date FY: 2019 ( Subtotal = $1,599,716 )
2019	2019	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	004	4	9/25/2019	NON-COMPETING CONTINUATION	$0
2019	2019	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	003	3	9/21/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	005	3	9/25/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	001	4	9/19/2019	NON-COMPETING CONTINUATION	$1,330,924
2019	2019	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	000	3	2/7/2019	SUPPLEMENT FOR EXPANSION	$186,828
2019	2019	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	002	4	9/21/2019	NON-COMPETING CONTINUATION	$81,964
														Subtotal = $1,599,716

Issue Date FY: 2018 ( Subtotal = $1,363,424 )
2018	2018	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	001	3	9/4/2018	COMPETING CONTINUATION	$1,363,424
2018	2017	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	000	2	8/30/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,363,424

Issue Date FY: 2017 ( Subtotal = $735,615 )
2017	2017	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	001	2	9/8/2017	NON-COMPETING CONTINUATION	$0
2017	2017	HESPEROS, INC	3259 PROGRESS DR, # 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	000	2	9/5/2017	NON-COMPETING CONTINUATION	$735,615
														Subtotal = $735,615

Issue Date FY: 2016 ( Subtotal = $1,241,321 )
2016	2016	HESPEROS, LLC	3259 PROGRESS DR RM 158	ORLANDO	FL	32826	ORANGE	USA	National Center for Advancing Translational Sciences	000	1	8/30/2016	NEW	$1,241,321
														Subtotal = $1,241,321

Grand Total All Awards = $6,496,067

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Populating MPS database with data from multi-organ, human-on-a-chip microphysiological systems

Award Number: R44TR001326

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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