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SUB-MILLIMETER SIMULTANEOUS SPECT-CT FOR IMAGING

Award Number: R44RR016393
ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2001
PERIOD OF PERFORMANCE END DATE: 06/30/2005

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SUB-MILLIMETER SIMULTANEOUS SPECT-CT FOR IMAGING - DESCRIPTION (provided by applicant): We are proposing to develop a single, bench-top animal scanner that will acquire both functional SPECT images and anatomical CT images with sub-millimeter spatial resolution for both imaging modalities. The sub-mm SPECT-CT will provide a technique for noninvasive functional imaging in mice for a wide range of applications, including the development of new radio-pharmaceuticals, assessment of new therapeutic approaches, and investigation of fundamental biological processes in transgenic and knockout mice. This would allow investigators to perform serial imaging studies in the same animal at multiple time points to investigate tumor growth, tissue pathology, the effects of therapy, and the mechanism of action of new diagnostic agents. The system will have wide applicability and significant impact in research that uses small animals to advance our understanding of human disease processes. During phase I we successfully completed all proposed feasibility studies to demonstrate SPECT/CT with gamma performance of 1.3mm intrinsic spatial resolution, E range from 30keV to 350keV, and,deltaE/E=12% at 140keV and - 100mu m CT capability from a 50xS0mm CMOS based digital x-ray detector. In addition, we acquired outstanding dual SPECT-CT images of euthanized mice. During the phase II project we will complete the integration of the high-resolution SPECT and transmission CT subsystems and develop all necessary hardware and software. The result will be a fully functional dual-modality prototype scanner for anatomical and quantitative metabolic imaging of small animals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $368,960 )
2004	2004	PHOTON IMAGING, INC	19355 BUSINESS CTR DR SUITE 8	NORTHRIDGE	CA	91324	LOS ANGELES	USA	National Center for Research Resources	000	3	6/30/2004	NON-COMPETING CONTINUATION	$368,960
														Subtotal = $368,960

Issue Date FY: 2003 ( Subtotal = $379,863 )
2003	2003	PHOTON IMAGING, INC	19355 BUSINESS CTR DR SUITE 8	NORTHRIDGE	CA	91324	LOS ANGELES	USA	Biomedical Technology	000	2	7/8/2003	COMPETING CONTINUATION	$379,863
														Subtotal = $379,863

Grand Total All Awards = $748,823

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SUB-MILLIMETER SIMULTANEOUS SPECT-CT FOR IMAGING

Award Number: R44RR016393

ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2001

PERIOD OF PERFORMANCE END DATE: 06/30/2005

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