Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Towards a Virtual Biopsy: An improved multimodal imaging biomarker to guide treatment decisions in neuro-oncology by combining advanced tissue microstructure imaging with deep learning

Award Number: R44NS120796
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2024

Group Awards By:

View Award Description

Towards a Virtual Biopsy: An improved multimodal imaging biomarker to guide treatment decisions in neuro-oncology by combining advanced tissue microstructure imaging with deep learning - Project Summary/Abstract Despite advances in surgery, radiotherapy, and chemotherapy, the prognosis for neuro- oncology patients remains poor, with a mean survival of 12-15 months for high-grade gliomas. One major reason for poor survival is that it remains difficult to accurately assess tumor progression and treatment-related changes on standard imaging. This limits necessary information for guiding biopsies or resecting malignant tissue. In addition, new therapies can cause radiological patterns that obfuscate the underlying course of the disease. As a result, there is a critical need for new quantitative imaging tools to evaluate brain tumors and their progression. The goal of this proposal is to develop novel quantitative imaging biomarkers using the combination of advanced tissue microstructure imaging and deep learning to accurately discriminate tumor from non-tumor tissue, measure tumor progression and treatment response, and predict clinical outcomes. This approach utilizes restricted spectrum imaging (RSI), an advanced diffusion-weighted imaging technique that models the restricted diffusion of water to improve tumor conspicuity. Phase I of this proposal will develop a hybrid multimodal, RSI-based biomarker for brain cancer, quantify the biomarker in abnormal sub-regions, and demonstrate the biomarker’s performance in predicting clinical outcomes. Phase II of this proposal will develop and deploy commercial-grade software to the CorTechs Labs cloud platform, demonstrate its clinical usability and utility, and generate the materials required for a 510K FDA submission. The AI technology developed through this proposal will ultimately serve as a clinical decision support tool to improve clinician performance in diagnosing and evaluating brain tumors and predicting tumor response to treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	CORTECHS LABS, INC.	5060 SHOREHAM PL STE 240	SAN DIEGO	CA	92122	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/8/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	CORTECHS LABS, INC.	5060 SHOREHAM PL STE 240	SAN DIEGO	CA	92122	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/31/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $254,685 )
2021	2021	CORTECHS LABS, INC.	5060 SHOREHAM PL STE 240	SAN DIEGO	CA	92122	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/22/2021	NEW	$254,685
														Subtotal = $254,685

Grand Total All Awards = $254,685

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Towards a Virtual Biopsy: An improved multimodal imaging biomarker to guide treatment decisions in neuro-oncology by combining advanced tissue microstructure imaging with deep learning

Award Number: R44NS120796

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer