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Non-invasive integrated system for brain stimulation and magnetocorticography

Award Number: R44NS090894
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2022

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Non-invasive integrated system for brain stimulation and magnetocorticography - DESCRIPTION (provided by applicant): Understanding the electrophysiology of neural circuits in the human brain is critical for advancing our knowledge of human nature since fast neural communication underlies our remarkable perceptual, motor, and cognitive abilities. Studying such networks requires a method to stimulate one or more nodes of any network with precise timing and a method to accurately measure electrophysiological activity with millisecond time resolution. At present, single-channel transcranial magnetic stimulation (TMS) devices are used to stimulate one focal region of the cortex and an array of EEG electrodes to measure the consequences of such stimulations on network functions. This type of device can stimulate only one region at a time with a rather diffuse area of stimulation and record brain activity smeared by the intervening scalp, skull and cerebral spinal fluid (CSF). We propose to develop and test a novel noninvasive system with the stimulation and recording capabilities required for understanding functional roles of neural circuits in the human brain with high time resolution. In this SBIR Fast-Track project, we will first test the basic 1-channel unit during Phase I. In Phase II, we will construct a 16-channel cryogenically cooled high-density TMS coil array integrated with a 25-channel TMS-compatible atomic gradiometer (AG) array. Phase I - Aim 1A: Construct a 1-channel cryoTMS system with a 30-mm OD coil encased in a tubular miniature cryostat with a 1-cm diameter hole in the middle and an OD of 38 mm and a remote-control positioning mechanism for radially moving the probe to touch the scalp. It will be connected to a liquid nitrogen (LN2) reservoir via a flexible transfer tube for cooling the TMS coil. Aim 1B: Construct an axial miniature AG encased in a rod-like 10 mm2 probe. Phase II - Aim 2A: Construct a 16- channel TMS coil array based on the 1-channel system with an automated positioning system, cooled by a closed-loop 100% LN2 recycler. Aim 2B: MagVenture will construct a 16-channel TMS stimulator specifically for this project and deliver it to Tristan for integration with the TMS system. Aim 2C: Construct a 25-channel AG array based on the 1-channel AG and a controller with a high laser pump power for shortening the recovery time after each TMS pulse to <2 ms We will develop techniques for mass production of these AGs using the MEMS technology. Aim 2D: Develop the software for controlling the TMS stimulator for targeting the E field to desired locations with optimal orientations. Aim 2E: Integrate the 16 TMS coils and 25 AG probes into a single system, inserting an AG probe into the middle hole of each cryostat and between the cryostats for high spatial resolution and test the functionality of the system. Phase II - Aim 3: Evaluate its capabilities on 20 healthy adult volunteers in a magnetic shielding enclosure, using the software capable of controlling the TMS system and measuring MEG signals in real time. We will test if the TMS-MEG system can be used to stimulate one or more nodes of a sensorimotor network and to study functional roles of each node of the network.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2018	TRISTAN TECHNOLOGIES, INC.	8860 KENAMAR DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	4/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/28/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $167,103 )
2018	2018	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/15/2018	NON-COMPETING CONTINUATION	$167,103
														Subtotal = $167,103

Issue Date FY: 2017 ( Subtotal = $498,671 )
2017	2017	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/26/2017	NON-COMPETING CONTINUATION	$498,671
														Subtotal = $498,671

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	TRISTAN TECHNOLOGIES, INC	6350 NANCY RIDGE DR SUITE 102	SAN DIEGO	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/12/2016	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $1,749,026 )
2015	2015	TRISTAN TECHNOLOGIES, INC	6185 Cornerstn CT E # 106	San Diego	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/6/2015	NEW	$399,516
2015	2015	TRISTAN TECHNOLOGIES, INC	6185 Cornerstn CT E # 106	San Diego	CA	92121	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/18/2015	EXTENSION WITH OR WITHOUT FUNDS	$1,349,510
														Subtotal = $1,749,026

Grand Total All Awards = $2,414,800

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Non-invasive integrated system for brain stimulation and magnetocorticography

Award Number: R44NS090894

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2022

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