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NeuroMAP System for Clinical Research

Award Number: R44NS077526
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2011
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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NeuroMAP System for Clinical Research - Motoneurons are the final neural circuits that link the brain with skeletal muscles to enable the body to move. Impairments in the ability to regulate movement currently affect over 50 million Americans suffering from various neurological or musculoskeletal conditions. Yet the deficits in motoneuron control that underlie many of these conditions are difficult to discern because current research tools used to measure motoneuron activity from skeletal muscles are limited to needle electromyography (EMG) recordings, which are invasive, yield the firings of just a few motoneurons, and are only applicable to highly constrained muscle contractions. Although recently developed surface EMG techniques present a noninvasive alternative, current systems provide only gross measures of muscle activation with little to no information about the underlying motoneuron firings that comprise the signal. Advanced assessment tools are therefore needed to provide clinical researchers with measurements of underlying deficits in motoneuron control to better understand, evaluate, and treat disabilities that limit motor function. Our recent Phase II SBIR prototype is poised to meet this need. We have developed a unique, non-invasive, post-processing system that accurately measures the firing behavior of individual motoneurons from body-worn sensors during gait, exercise and activities of daily living. Through this Phase IIB SBIR, we now propose to advance our complex laboratory-based prototype into a turn-key, real- time NeuroMAP™ system that meets versatility, usability and feasibility requirements for commercialization in the clinical research marketplace. We will integrate the existing multi-component system into a usable, wearable and mobile compatible system of wireless sensors with conformable skin-sensor interfaces to support use-cases across multiple muscles, movements, and clinical test procedures. The present post-processing software architecture will be redesigned with real-time algorithms, advanced user-interfaces and automated reporting of motoneuron measurements for intuitive, user-friendly operation. The usability and feasibility of our device will be tested among five leading clinical research partners across the fields of adult and pediatric neurology, physical therapy, sports rehabilitation and biomedical engineering. Through these efforts, and through strategic investments to support the regulatory strategy, manufacturing process and marketing plan from our industry partner, Delsys, Inc, we will deliver an impactful, usable and validated NeuroMAP™ system ready for production, marketing and sales within 1 year of completing this award. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	ALTEC INC	23 STRATHMORE RD	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	5/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $535,902 )
2020	2020	ALTEC INC	23 STRATHMORE RD.	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	4/16/2020	NON-COMPETING CONTINUATION	$535,902
														Subtotal = $535,902

Issue Date FY: 2019 ( Subtotal = $635,201 )
2019	2019	ALTEC INC	23 STRATHMORE RD.	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	5/1/2019	NON-COMPETING CONTINUATION	$629,721
2019	2018	ALTEC INC	23 STRATHMORE RD.	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	6/10/2019	COMPETING CONTINUATION	$5,480
2019	2016	ALTEC INC	23 STRATHMORE RD.	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	6/26/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $635,201

Issue Date FY: 2018 ( Subtotal = $793,693 )
2018	2018	ALTEC INC	23 STRATHMORE RD.	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	6/29/2018	COMPETING CONTINUATION	$793,693
														Subtotal = $793,693

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	ALTEC INC	23 STRATHMORE RD.	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	4/13/2017	NON-COMPETING CONTINUATION	-$5,480
2017	2014	ALTEC INC	23 STRATHMORE RD.	NATICK	MA	01760	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/12/2017	COMPETING CONTINUATION	$5,480
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $498,514 )
2016	2016	ALTEC, INC	POST OFFICE BOX 15622	BOSTON	MA	02215	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/15/2015	NON-COMPETING CONTINUATION	$498,514
														Subtotal = $498,514

Issue Date FY: 2015 ( Subtotal = $523,940 )
2015	2015	ALTEC, INC	POST OFFICE BOX 15622	BOSTON	MA	02215	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	4/9/2015	NON-COMPETING CONTINUATION	$518,940
2015	2015	ALTEC, INC	POST OFFICE BOX 15622	BOSTON	MA	02215	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	6/23/2015	SUPPLEMENT FOR EXPANSION	$5,000
2015	2014	ALTEC, INC	POST OFFICE BOX 15622	BOSTON	MA	02215	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/17/2015	COMPETING CONTINUATION	$0
														Subtotal = $523,940

Issue Date FY: 2014 ( Subtotal = $534,212 )
2014	2014	ALTEC, INC	POST OFFICE BOX 15622	BOSTON	MA	02215	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/25/2014	COMPETING CONTINUATION	$534,212
														Subtotal = $534,212

Grand Total All Awards = $3,521,462

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NeuroMAP System for Clinical Research

Award Number: R44NS077526

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2011

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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