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Portable Brain Injury Biomarker Detection System with Integrated Microdialysis Pr

Award Number: R44NS076167
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2011
PERIOD OF PERFORMANCE END DATE: 04/26/2017

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Portable Brain Injury Biomarker Detection System with Integrated Microdialysis Pr - DESCRIPTION (provided by applicant): Portable Brain Injury Biomarker Detection System with Integrated Microdialysis Probe Project Summary: SFC Fluidics is developing a portable, fully-integrated and automated medical device for clinical monitoring of patients with severe brain injury. The instrument will allow for automated detection of several small molecule biomarkers, glucose, glutamate, lactate, pyruvate and urea, and a protein biomarker, S100B. These biomarkers are present in the extracellular fluid in the brain and continuous real-time monitoring of their concentration will provide important clues about adverse secondary insults like ischemia, hypoxia, seizure, vasospasm and more, and will help in critical care of patients in neuro-ICU. SFC Fluidics will use a suite of proven, patented technologies to develop the proposed instrument and make it ready for FDA approval and subsequent clinical trials in Phase III. SFC's innovative component technologies have been tested and assembled into an initial prototype, whose basic functionality has been demonstrated during Phase I. During Phase II, SFC will systematically and iteratively improve the design and functionality of the existing prototype, conduct extensive side-by-side, in vitro and in vivo testing and validate performance in an established rat model. The targeted instrument will integrate many clinically relevant and useful features to significantly change the modality of critical care of neurotrauma patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$830 )
2019	2016	SFC FLUIDICS, INC.	534 W RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	9/24/2019	NON-COMPETING CONTINUATION	-$830
														Subtotal = -$830

Issue Date FY: 2017 ( Subtotal = -$239,151 )
2017	2016	SFC FLUIDICS, INC.	534 W RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/4/2017	NON-COMPETING CONTINUATION	-$239,151
2017	2016	SFC FLUIDICS, INC.	534 W RESEARCH CENTER BLVD STE 260	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/29/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = -$239,151

Issue Date FY: 2016 ( Subtotal = $706,733 )
2016	2016	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/22/2016	NON-COMPETING CONTINUATION	$706,733
														Subtotal = $706,733

Issue Date FY: 2015 ( Subtotal = $747,835 )
2015	2015	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/11/2015	NON-COMPETING CONTINUATION	$747,835
														Subtotal = $747,835

Issue Date FY: 2014 ( Subtotal = $532,640 )
2014	2014	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/24/2014	COMPETING CONTINUATION	$15,238
2014	2014	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/26/2013	COMPETING CONTINUATION	$517,402
														Subtotal = $532,640

Grand Total All Awards = $1,747,227

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Portable Brain Injury Biomarker Detection System with Integrated Microdialysis Pr

Award Number: R44NS076167

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2011

PERIOD OF PERFORMANCE END DATE: 04/26/2017

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