Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

High-Field MR Compatible Dense Array EEG using Polymer Thick Film Technology

Award Number: R44NS071988
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2010
PERIOD OF PERFORMANCE END DATE: 12/31/2018

Group Awards By:

View Award Description

High-Field MR Compatible Dense Array EEG using Polymer Thick Film Technology - DESCRIPTION (provided by applicant): The goal of this SBIR project is to design a low-profile, high-resistive, MR-compatible dense-array EEG (dEEG) sensor net for simultaneous dEEG/fMRI recordings in fields as high as 7 Tesla. This novel sensor net, the "InkNet", will provide safe, noninvasive, and affordable dEEG/fMRI technology to both clinicians and researchers, thereby enabling routine multimodal imaging of human brain function with unprecedented spatiotemporal resolution. Application of this technology will enhance basic science of healthy brain function, as well as treatment of many neural pathologies and pre-surgical planning. The InkNet will overcome current cross-modal safety and artifact issues that have so far severely limited the effectiveness of simultaneous dEEG/fMRI by leveraging expertise in innovative polymer thick film (PTF) technology at the A. A. Martinos Center, Massachusetts General Hospital and dEEG sensor net design and technology expertise at Electrical Geodesics Inc. (EGI). In Phase I, we established feasibility with the development and testing of our first 256- channel InkNet prototype using screen-printed high-resistive PTF ink leads interfaced with EGI's patented geodesic net structure and MR-compatible EEG acquisition hardware and software. Phase II will build on the successes of our Phase I prototype while working to refine its design, enhance production manufacturability and cost efficiency, and conduct performance and safety tests. Specific Aim 1 is to study the latest innovations in flexible and stretchable substrates and conductive inks to improve conformability and electrode contact, and reduce MR-induced ballistocardiogram artifact. Sample circuits using the best candidate materials will be printed in-house and put to rigorous testing for optimal performance in high MR fields. Specific Aim 2 will refine the InkNet design, including an electrode pedestal with an ultra low profile of d4 mm to fit in tight MR head coils, and a novel lead layout enabled by state-of-the-art inkjet printing of leads up to 2.5 meters in length, double-sided, 5-mil trace width, and te novel, flexible materials. Specific Aim 3 will implement the new design and materials to produce Phase II 256-channel InkNet prototypes using QA production and test procedures and new, custom-designed assembly and test fixtures to enhance speed and reliability. Specific Aim 4 will test and validate the Phase II prototype for human safety and data integrity. Safety tests will be performed using finite difference time domain (FDTD) numerical simulations with an anatomically accurate head model, followed by actual temperature measurements using a specially developed phantom (CHEMA) and high-power TSE imaging sequences that induce RF heating. After confirming safety, MRI and EEG data integrity will be tested at 3T and 7T field strengths using clinically relevant structural scans, and fMRI/EEG resting, visual and auditory protocols. Data quality will be compared to data from EEG-only and MRI-only sessions, and against data from a commercial MR-compatible net built with traditional copper wire technology. Our test plan will be reviewed with FDA and adjusted where required to meet requirements for a 510K predicate application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$92,758 )
2019	2016	ELECTRICAL GEODESICS, INC.	500 E 4TH AVE # 200	EUGENE	OR	97401	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	4/9/2019	NON-COMPETING CONTINUATION	$6,349
2019	2016	ELECTRICAL GEODESICS, INC.	500 E 4TH AVE # 200	EUGENE	OR	97401	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	2/18/2019	NON-COMPETING CONTINUATION	-$99,107
2019	2016	ELECTRICAL GEODESICS, INC.	500 E 4TH AVE # 200	EUGENE	OR	97401	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/18/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = -$92,758

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	ELECTRICAL GEODESICS, INC.	500 E 4TH AVE # 200	EUGENE	OR	97401	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/20/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $592,046 )
2016	2016	ELECTRICAL GEODESICS, INC	1600 MILLRACE DRIVE, STE 307	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	8/3/2016	NON-COMPETING CONTINUATION	$592,046
														Subtotal = $592,046

Issue Date FY: 2015 ( Subtotal = $594,948 )
2015	2015	ELECTRICAL GEODESICS, INC	1600 MILLRACE DRIVE, STE 307	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/16/2015	NON-COMPETING CONTINUATION	$594,948
														Subtotal = $594,948

Issue Date FY: 2014 ( Subtotal = $561,798 )
2014	2014	ELECTRICAL GEODESICS, INC	1600 MILLRACE DRIVE, STE 307	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	7/15/2014	COMPETING CONTINUATION	$561,798
														Subtotal = $561,798

Grand Total All Awards = $1,656,034

Top

All Categories

About

Search

Reports

Data Submission

Award Information

High-Field MR Compatible Dense Array EEG using Polymer Thick Film Technology

Award Number: R44NS071988

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2010

PERIOD OF PERFORMANCE END DATE: 12/31/2018

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer