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An Intuitive Prosthetic System for Upper Extremity Amputees

Award Number: R44NS065495
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2008
PERIOD OF PERFORMANCE END DATE: 08/31/2016

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An Intuitive Prosthetic System for Upper Extremity Amputees - DESCRIPTION (provided by applicant): There are well over 100,000 people living with upper limb loss in the United States today and 1 in 12 new amputations are of the upper limb. The loss of an upper limb is devastating to a person's quality of life, their work productivity and it bring about many psychosocial challenges. While there have been exciting technological advances which promise the availability of dexterous prosthetic hands, there is a wide gulf between what is technically possible and the reality faced by the overwhelming majority of amputees. In short, there is a need for an integrated cost-effective prosthetic system which can reliably control multiple degrees of freedom. In a direct response, and in accordance with the scope of PA-11-135 as related to the development and integration of complex instrumentation, we now propose an SBIR Phase IIB effort to develop such a system, based on the following innovative solutions: 1) the MyoLiner: a textile-electrode based system for comfortable all-day acquisition of multichannel "high- definition" electromyograms (HD-EMG); 2) the PRO-Controller: a novel classifier algorithm and associated electronic hardware for decoding intentionality of coordinated hand movements; and 3) FlexCells: flexible high energy-density batteries that are conformal and adaptive to the limb. These technologies will be integrated for the first time with dexterous hand technology from our commercial partner to create an affordable, highly functional prosthesis, the Pattern-Recognition-Operated Arm (PRO- Arm). The system will be tested in a study designed to evaluate performance on an objective basis as well as from the standpoint of the patient. Of note, our goal is to have significant clinical impact, starting far before the end of the project. First, we have already launched FlexCells into the market and they have been well received. Second, we will prepare the MyoLiner system for clinical launch within the first year of the project. Third, we will build the system in a modular fashion, thereby allowing prosthetists to utilize the components with other companies' products. Fourth, the algorithm development and training is focused on real-world performance over the course of the day, not just idealized performance in the lab setting. And finally, fifth, the system will be sold to prosthetists well wihin the existing Medicare reimbursement codes - thus, there should be no financial impediments to clinical adoption of the technology. In short, we believe that this Phase IIB grant will enable us o bring this project, initiated through NIH support, to its logical conclusion. We will bring the PRO Arm into clinical use: an affordable but innovative solution, providing significant benefits to uppr extremity amputees.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$1 )
2017	2015	INFINITE BIOMEDICAL TECHNOLOGIES, LLC	1101 E 33RD ST STE E305	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	2/21/2017	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2015 ( Subtotal = $800,000 )
2015	2015	INFINITE BIOMEDICAL TECHNOLOGIES LLC	2352 Huntington Dr	Pasadena	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	2/19/2015	NON-COMPETING CONTINUATION	$800,000
														Subtotal = $800,000

Issue Date FY: 2014 ( Subtotal = $800,000 )
2014	2014	INFINITE BIOMEDICAL TECHNOLOGIES LLC	2352 Huntington Dr	Pasadena	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/19/2014	NON-COMPETING CONTINUATION	$800,000
														Subtotal = $800,000

Issue Date FY: 2013 ( Subtotal = $800,000 )
2013	2013	INFINITE BIOMEDICAL TECHNOLOGIES LLC	2352 Huntington Dr	Pasadena	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	2/27/2013	COMPETING CONTINUATION	$800,000
2013	2010	INFINITE BIOMEDICAL TECHNOLOGIES LLC	1613 chelsea rd #330	PASADENA	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	10/22/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $800,000

Issue Date FY: 2010 ( Subtotal = $614,890 )
2010	2010	INFINITE BIOMEDICAL TECHNOLOGIES LLC	2352 Huntington Dr	Pasadena	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/12/2010	NON-COMPETING CONTINUATION	$614,890
														Subtotal = $614,890

Issue Date FY: 2009 ( Subtotal = $469,174 )
2009	2009	INFINITE BIOMEDICAL TECHNOLOGIES LLC	2352 Huntington Dr	Pasadena	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/28/2009	NON-COMPETING CONTINUATION	$469,174
2009	2008	INFINITE BIOMEDICAL TECHNOLOGIES LLC	1613 chelsea rd #330	PASADENA	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/10/2008	NEW	$0
														Subtotal = $469,174

Issue Date FY: 2008 ( Subtotal = $270,105 )
2008	2008	INFINITE BIOMEDICAL TECHNOLOGIES LLC	1613 chelsea rd #330	PASADENA	CA	91108	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/12/2008	NEW	$270,105
														Subtotal = $270,105

Grand Total All Awards = $3,754,168

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An Intuitive Prosthetic System for Upper Extremity Amputees

Award Number: R44NS065495

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2008

PERIOD OF PERFORMANCE END DATE: 08/31/2016

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