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DEVELOPMENT OF SUB-SECOND 3D PULSE SEQUENCES FOR FMRI IN NEUROSCIENCES

Award Number: R44NS063537
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2008
PERIOD OF PERFORMANCE END DATE: 02/28/2013

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DEVELOPMENT OF SUB-SECOND 3D PULSE SEQUENCES FOR FMRI IN NEUROSCIENCES - DESCRIPTION (provided by applicant): MRI is a proven non-invasive technique to make functional MRI (fMRI) by measuring changes in "blood oxygen level dependent" (BOLD) contrast in different regions of the brain resulting from the neurovascular coupling of neuronal activity. Echo planar imaging (EPI) is the most widely used fMRI pulse sequence, due to its speed and BOLD contrast, however EPI has relatively poor image quality due to distortions and signal missing from brain regions of high susceptibility near bone and air interfaces. In high spatial resolution (sub-millimeter) fMRI at 7T to explore the functional organization of the cortex, EPI is limited to single 2D image slice that cannot reveal the true 3D distribution of neuronal activity. We are proposing of the development of a family of highly efficient 3D fMRI pulse sequences which obtain sub-second 3D images of the brain, optimized for BOLD contrast in fMRI. The sequences will utilize gradient-and-spin-echo (GRASE) pulse sequence which is hybridized and modified to obtain BOLD contrast in high spatial resolution and minimal artifacts. The new 3D fMRI sequences will be designed and implemented to reduce or eliminate the susceptibility related artifacts of distortion and signal loss in EPI. The availability of these 3D fMRI pulse sequences will give researchers and clinicians the capability of performing fMRI of the brain with improvements over current 2D fMRI methodology. The sequence will be designed and implemented on a 1.5T MR scanner. The new sequences will be ported to 3T and 7T high field scanners at University of California Berkeley, University of Minnesota and UCSF where the new imaging technology will undergo further optimization and testing in neuroscience studies. PUBLIC HEALTH RELEVANCE: Functional MRI (fMRI) is a widely used method to study the brain while it is performing thinking tasks and to map out regions of brain activity. We are proposing a sub-second 3D imaging technology to be supplement or replace the current use of sub-second 2D imaging for fMRI. The 3D fMRI will be useful for revealing the basic organization of the brain's activity which could lead to new discoveries of how the brain works. The resulting measurements obtained in the brain with 3D fMRI will be useful for studies of neurodegenerative diseases including Alzheimer's disease, drug trials and for evaluating people with stroke and cerebrovascular diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2010	ADVANCED MRI TECHNOLOGY, INC	652 PETALUMA, SUITE J	SEBASTOPOL	CA	95472	SONOMA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	7/13/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $374,920 )
2010	2010	ADVANCED MRI TECHNOLOGY, INC	652 PETALUMA, SUITE J	SEBASTOPOL	CA	95472	SONOMA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/10/2010	NON-COMPETING CONTINUATION	$374,920
														Subtotal = $374,920

Issue Date FY: 2009 ( Subtotal = $373,660 )
2009	2009	ADVANCED MRI TECHNOLOGY, INC	652 PETALUMA, SUITE J	SEBASTOPOL	CA	95472	SONOMA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	6/10/2009	NON-COMPETING CONTINUATION	$374,920
2009	2008	ADVANCED MRI TECHNOLOGY, INC	652 PETALUMA, SUITE J	SEBASTOPOL	CA	95472	SONOMA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/31/2008	NEW	$0
2009	2008	ADVANCED MRI TECHNOLOGY, INC	652 PETALUMA, SUITE J	SEBASTOPOL	CA	95472	SONOMA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	6/8/2009	NEW	-$1,260
														Subtotal = $373,660

Issue Date FY: 2008 ( Subtotal = $101,500 )
2008	2008	ADVANCED MRI TECHNOLOGY, INC	652 PETALUMA, SUITE J	SEBASTOPOL	CA	95472	SONOMA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/11/2008	NEW	$101,500
														Subtotal = $101,500

Grand Total All Awards = $850,080

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DEVELOPMENT OF SUB-SECOND 3D PULSE SEQUENCES FOR FMRI IN NEUROSCIENCES

Award Number: R44NS063537

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2008

PERIOD OF PERFORMANCE END DATE: 02/28/2013

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