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FUNCTIONALIZED COATINGS FOR ENHANCED NEURAL INTERFACES

Award Number: R44NS049687
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/20/2004
PERIOD OF PERFORMANCE END DATE: 08/31/2011

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FUNCTIONALIZED COATINGS FOR ENHANCED NEURAL INTERFACES - DESCRIPTION (provided by applicant): The development of a biologically active coating for electrodes used in recording and stimulation of the nervous system is proposed. The coating is based on a co-polymer of poly(ethylene glycol)/polylactic acid (PEG-PLA) that contains a neurotrophic factor as a slowly releasable constituent. Release of the neurotrophin promotes the extension of neural processes to the electrode surface. The close proximity of the electrode to viable neural processes will enhance the stability and sensitivity of neural recordings and may reduce charge- injection thresholds for neural excitation. Surface treatment of electrodes with cell adhesion peptides will also be evaluated as a means of preserving the interface once the neurotrophic factor is exhausted. Our objectives for the Phase II effort are 1) to assess the benefits of neurotrophin-eluting polymers on microelectrodes implanted in an animal model appropriate to intracortical recording for direct thought-based control of extracorporal devices for the spinal cord injured, 2) to assess the benefit of neurotrophin-eluting coatings on stimulation electrodes in a model of neurodegenerative disease, specifically retinal stimulation electrodes in visual prostheses for retinitis pigmentosa, and 3) to evaluate the use of surface-bound coatings of peptide adhesion molecules to chronically stabilize the close proximity of neural processes at the electrode surface established by short-term neurotrophin elution. Prostheses are being developed for individuals with spinal cord injury, deafness, blindness and diseases that impair movement. These prostheses will function by electrically stimulating nerves or by recording nerve activity in the brain. The use of biodegradable coatings on these electrodes to enhance the electrical connection between the implanted metal electrodes and nerve cells in the brain is proposed. The coatings will elute biologically active molecules that encourage nerve cells to grow to the implanted electrodes, increasing the efficiency and reliability of the stimulation and recording properties of the prostheses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2007	EIC LABORATORIES, INC	111 DOWNEY STREET	NORWOOD	MA	02062	NORFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	7/23/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	EIC LABORATORIES, INC	111 DOWNEY STREET	NORWOOD	MA	02062	NORFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/5/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $826,833 )
2007	2007	EIC LABORATORIES, INC	111 DOWNEY STREET	NORWOOD	MA	02062	NORFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/27/2007	NON-COMPETING CONTINUATION	$826,833
														Subtotal = $826,833

Issue Date FY: 2006 ( Subtotal = $550,992 )
2006	2006	EIC LABORATORIES, INC	111 DOWNEY STREET	NORWOOD	MA	02062	NORFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/30/2006	COMPETING CONTINUATION	$550,992
														Subtotal = $550,992

Grand Total All Awards = $1,377,825

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FUNCTIONALIZED COATINGS FOR ENHANCED NEURAL INTERFACES

Award Number: R44NS049687

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/20/2004

PERIOD OF PERFORMANCE END DATE: 08/31/2011

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