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IN VIVO SCREEN FOR NEUROPROTECTIVE AGENTS

Award Number: R44NS048607
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2004
PERIOD OF PERFORMANCE END DATE: 05/31/2010

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IN VIVO SCREEN FOR NEUROPROTECTIVE AGENTS - DESCRIPTION (provided by applicant): Neuronal apoptosis has been shown to be involved in pathogenesis of several neurodegenerative disorders including Parkinson's Disease (PD), Alzheimer's Disease (AD), Amyotophic Lateral Sclerosis (ALS) and stroke. Currently, there is no simple method to assess neuronal apoptosis or neuroprotection in vivo in vertebrates. Furthermore, conventional vertebrate assays, which are lengthy and laborious, are impractical for screening compound libraries. A validated in vivo assay will be useful for prescreening drug candidates prior to performing expensive mammalian testing. The overall aim of this research is to develop a rapid, quantitative in vivo zebrafish assay to identify potential neuroprotectants. Phase I research established a reproducible model for generating apoptosis in the brain and developed methods for screening neuroprotectants in vivo. Phase II research will automate the assay to increase screening throughput, perform a pilot screen using a compound library and confirm neuroprotective effects of "hit" compounds using a conventional mammalian model. By providing a rapid in vivo assay for prescreening drug candidates prior to performing expensive mammalian testing, the proposed zebrafish assay will facilitate drug development for neurodegenerative disorders and stroke.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = -$16,573 )
2011	2009	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	12/20/2010	NON-COMPETING CONTINUATION	-$2,658
2011	2008	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/20/2010	NON-COMPETING CONTINUATION	-$8,939
2011	2007	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	12/20/2010	COMPETING CONTINUATION	-$4,976
														Subtotal = -$16,573

Issue Date FY: 2009 ( Subtotal = $375,734 )
2009	2009	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/25/2009	NON-COMPETING CONTINUATION	$300,216
2009	2009	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Trans-NIH Recovery Act Research Support	001	4	9/16/2009	SUPPLEMENT FOR EXPANSION	$75,518
														Subtotal = $375,734

Issue Date FY: 2008 ( Subtotal = $352,818 )
2008	2008	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/7/2008	NON-COMPETING CONTINUATION	$352,818
														Subtotal = $352,818

Issue Date FY: 2007 ( Subtotal = $362,566 )
2007	2007	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/23/2007	COMPETING CONTINUATION	$362,566
														Subtotal = $362,566

Grand Total All Awards = $1,074,545

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IN VIVO SCREEN FOR NEUROPROTECTIVE AGENTS

Award Number: R44NS048607

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2004

PERIOD OF PERFORMANCE END DATE: 05/31/2010

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