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WIRELESS MOVEMENT DISORDER MONITOR

Award Number: R44NS043816
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2002
PERIOD OF PERFORMANCE END DATE: 11/30/2010

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WIRELESS MOVEMENT DISORDER MONITOR - DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess a Wireless Movement Disorder Monitor (WMDM) specifically tailored to Parkinson's disease (PD). Major PD symptoms that affect quality of life include tremor, bradykinesia, rigidity, and dyskinesias. Objectively quantifying symptoms would aid in evaluating efficacy of treatment protocols. Monitoring symptoms at home would allow clinicians to capture complex fluctuation patterns in response to treatment protocols. Phase I illustrated that severity of tremor and bradykinesia could be monitored using a small, lightweight, untethered finger worn system utilizing accelerometers and gyroscopes. During Phase II we will upgrade the hardware and software and complete a large clinical trial. A new radio and mounting design will provide a smaller and more comfortable untethered patient unit. The upgraded software interface will include clinical video, a patient database, and remote data access. New detection algorithms will incorporate dyskinesia detection. The WMDM will be clinically tested both in the clinic and in the homes of PD subjects. We hypothesize that the WMDM will capture symptom variables that correlate to qualitative clinical scoring of tremor, bradykinesia, rigidity, and dyskinesias. In addition, the WMDM should be successfully used in the homes of PD subjects with high system acceptance


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $807,576 )
2009	2009	CLEVELAND MEDICAL DEVICES, INC	4415 EUCLID AVENUE	CLEVELAND	OH	44103	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	11/19/2008	NON-COMPETING CONTINUATION	$807,576
2009	2005	CLEVELAND MEDICAL DEVICES, INC	4415 EUCLID AVENUE	CLEVELAND	OH	44103	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/19/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $807,576

Issue Date FY: 2008 ( Subtotal = $678,005 )
2008	2008	CLEVELAND MEDICAL DEVICES, INC	4415 EUCLID AVENUE	CLEVELAND	OH	44103	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/27/2008	SUPPLEMENT FOR EXPANSION	$2,727
2008	2008	CLEVELAND MEDICAL DEVICES, INC	4415 EUCLID AVENUE	CLEVELAND	OH	44103	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/11/2007	COMPETING CONTINUATION	$675,278
														Subtotal = $678,005

Issue Date FY: 2005 ( Subtotal = $381,452 )
2005	2005	CLEVELAND MEDICAL DEVICES, INC	11000 CEDAR AVE, STE 461	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/26/2005	NON-COMPETING CONTINUATION	$381,452
														Subtotal = $381,452

Issue Date FY: 2004 ( Subtotal = $521,427 )
2004	2004	CLEVELAND MEDICAL DEVICES, INC	11000 CEDAR AVE, STE 461	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/1/2004	COMPETING CONTINUATION	$521,427
														Subtotal = $521,427

Grand Total All Awards = $2,388,460

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WIRELESS MOVEMENT DISORDER MONITOR

Award Number: R44NS043816

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2002

PERIOD OF PERFORMANCE END DATE: 11/30/2010

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