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Novel strategies for storage and recovery of cadaveric bone marrow stem cells

Award Number: R44HL142418
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2018
PERIOD OF PERFORMANCE END DATE: 02/28/2023

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Novel strategies for storage and recovery of cadaveric bone marrow stem cells - ABSTRACT Bone marrow represents a rich source of diverse stem, progenitor and other cells of clinical and research interest including hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC), dendritic cells, T-cells, natural killer (NK) cells, B-cells and others. Currently, these cells are only recovered from living donors through bone marrow aspiration or peripheral blood mobilization. Ossium Health is developing the first clinical and research bank of bone marrow derived cells from deceased organ and tissue donors. While the concept of utilizing this resource for bone marrow cells was first described over 60 years ago, the ability to recover viable material efficiently and the infrastructure necessary to achieve this at even a modest scale simply has not existed. Ossium Health has overcome this by establishing a robust ecosystem comprised of a world-class tissue processor (and Phase III partner), major organ procurement agencies and innovation to, for the first time, allow recovery and banking of this plentiful source of potentially life-saving cells. However, for this bank to reach its full potential, further efficiencies must be advanced and implemented. This Phase II study aims to develop “smart baking” innovations by optimizing methods of cryopreserving intact marrow in situ within whole bones to allow time for infectious disease, sterility and HLA testing prior to investing in fully processing donor bones to isolate cellular components. This innovative work will also provide early guidance towards cryopreservation of more complex tissues such as vascular composite allografts (VCA). The resulting technology from this study may increase efficiency by as much as 80% - drastically reducing cost and allowing more readily available and less expensive clinical grade and high-quality research material to be available to meet the growing demands of gene therapy, tissue engineering and basic science investigation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	OSSIUM HEALTH, INC.	78 TEHAMA ST	SAN FRANCISCO	CA	94105	SAN FRANCISCO	USA	Blood Diseases and Resources Research	000	3	12/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $687,302 )
2021	2021	OSSIUM HEALTH, INC.	1121 HOWARD ST	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Blood Diseases and Resources Research	001	3	2/17/2021	NON-COMPETING CONTINUATION	$687,302
2021	2020	OSSIUM HEALTH, INC.	1121 HOWARD ST	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Blood Diseases and Resources Research	000	2	10/26/2020	COMPETING CONTINUATION	$0
														Subtotal = $687,302

Issue Date FY: 2020 ( Subtotal = $778,661 )
2020	2020	OSSIUM HEALTH, INC.	25 TAYLOR ST	SAN FRANCISCO	CA	94102	SAN FRANCISCO	USA	Blood Diseases and Resources Research	000	2	2/28/2020	COMPETING CONTINUATION	$778,661
														Subtotal = $778,661

Grand Total All Awards = $1,465,963

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Novel strategies for storage and recovery of cadaveric bone marrow stem cells

Award Number: R44HL142418

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2018

PERIOD OF PERFORMANCE END DATE: 02/28/2023

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