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Improving safety and efficacy of platelet transfusion through systems biology

Award Number: R44HL127843
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2021

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Improving safety and efficacy of platelet transfusion through systems biology - Project Summary Platelet transfusion is critical for severely bleeding patients and nearly 6 million units are transfused in the United States and Europe annually. In the United States, platelets are typically stored for 5 days resulting in a waste of 20% of their supply. Short storage duration is a consequence of bacterial contamination and platelet quality considerations. Though many methods have been developed for bacterial testing and pathogen inactivation, fewer have been developed for improving quality of stored platelets. Platelet additive solutions have the possibility to increase storage quality and duration, reduce plasma-related allergic reactions, impact the efficacy of pathogen reduction techniques, and save plasma which can then be used as an additional transfusion product. While the benefits are well known, there has been little progress in developing new platelet additive solutions for increasing quality and safety of platelet transfusion because there is a lack of broad understanding of biochemical and signaling changes during storage. There has been interest to utilize high-throughput metabolite profiling for global understanding of platelet metabolic decline but data analysis of complex datasets has been a daunting challenge. In Phase I of this program, we developed the first, robust computational platform involving statistical analysis and systems biology of metabolic and signaling networks to interpret and analyze PLT metabolomic and proteomic profiles in a complete network context. Using time- course global, quantitative metabolite profiling, we determined that PLTs undergo a non-linear decay process and computationally identified key metabolic enzymes and cellular process that drive this decay. Based on the computational results, we have devised two novel additive solution strategies to mitigate the decay process and improve the length of PLT units. In this Phase II proposal, we will validate the computationally determined additive solutions for efficacy in alleviating the non-linear decay process through 1) metabolomics experiments, and 2) non-metabolic PLT physiology experiments including cell activation and hemostatic effectiveness. A successful additive solution will be progressed to media refinement and preclinical testing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$1 )
2022	2018	SINOPIA BIOSCIENCES, INC.	3210 MERRYFIELD ROW	SAN DIEGO	CA	92121	SAN DIEGO	USA	Blood Diseases and Resources Research	000	3	10/28/2021	NON-COMPETING CONTINUATION	$0
2022	2018	SINOPIA BIOSCIENCES, INC.	3210 MERRYFIELD ROW	SAN DIEGO	CA	92121	SAN DIEGO	USA	Blood Diseases and Resources Research	001	3	5/18/2022	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	SINOPIA BIOSCIENCES, INC.	600 W BROADWAY SUITE 700	SAN DIEGO	CA	92101	SAN DIEGO	USA	Blood Diseases and Resources Research	000	3	3/9/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $428,727 )
2018	2018	SINOPIA BIOSCIENCES, INC.	600 W BROADWAY SUITE 700	SAN DIEGO	CA	92101	SAN DIEGO	USA	Blood Diseases and Resources Research	000	3	3/21/2018	NON-COMPETING CONTINUATION	$428,727
														Subtotal = $428,727

Issue Date FY: 2017 ( Subtotal = $1,099,022 )
2017	2017	SINOPIA BIOSCIENCES, INC.	600 W BROADWAY SUITE 700	SAN DIEGO	CA	92101	SAN DIEGO	USA	Blood Diseases and Resources Research	000	2	6/14/2017	COMPETING CONTINUATION	$1,099,022
														Subtotal = $1,099,022

Grand Total All Awards = $1,527,748

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Improving safety and efficacy of platelet transfusion through systems biology

Award Number: R44HL127843

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2021

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