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Improving red blood cell transfusion through systems biology

Award Number: R44HL123074
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/19/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2019

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Improving red blood cell transfusion through systems biology - DESCRIPTION (provided by applicant): Red blood cells (RBC) stored in approved additive solutions undergo a set of metabolic and physicochemical changes referred to as `storage lesions' reducing the efficacy and safety of older transfused RBC units. Though the consequences of the storage lesion are slowly becoming well documented, a major reason for delayed progress in developing new technologies for quality and safety of RBC transfusion is the lack of global understanding of metabolic decline during storage. There has been interest to utilize high-throughput metabolite profiling for global understanding of RBC metabolic decline but data analysis of complex datasets has been a daunting challenge. In Phase I of this program, we developed the first, robust computational platform involving statistical analysis, systems biology of metabolic networks, and data-driven kinetic models to fully interpret and analyze RBC metabolite-profiles in a complete network context. Using time-course global, quantitative metabolite profiling, we determined that RBCs undergo a clinically relevant non-linear decay process and computationally identified key metabolic enzymes that drive this decay process. Based on the computational results, we have devised two novel additive solution strategies to mitigate the decay process and improve the safety and accuracy of RBC transfusion. In this proposal, we will validate the computationally determined additive solutions for efficacy in alleviating the non-linear decay process through 1) metabolomics experiments, and 2) non-metabolic RBC physiology experiments including cell rheology and microparticle generation. A successful additive solution will be progressed to media refinement and preclinical testing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	SINOPIA BIOSCIENCES, INC.	600 W BROADWAY SUITE 700	SAN DIEGO	CA	92101	SAN DIEGO	USA	Blood Diseases and Resources Research	000	3	11/14/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $443,351 )
2017	2017	SINOPIA BIOSCIENCES, INC.	600 W BROADWAY SUITE 700	SAN DIEGO	CA	92101	SAN DIEGO	USA	Blood Diseases and Resources Research	000	3	5/26/2017	NON-COMPETING CONTINUATION	$443,351
														Subtotal = $443,351

Issue Date FY: 2016 ( Subtotal = $1,029,290 )
2016	2016	SINOPIA BIOSCIENCES INC	600 WEST BROADWAY	SAN DIEGO	CA	92101	SAN DIEGO	USA	Cardiovascular Diseases Research	000	2	8/15/2016	COMPETING CONTINUATION	$1,029,290
														Subtotal = $1,029,290

Grand Total All Awards = $1,472,641

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Improving red blood cell transfusion through systems biology

Award Number: R44HL123074

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/19/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2019

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