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PULSE CO-OXIMETER FOR MULTIPLE HEMOGLOBIN SPECIES

Award Number: R44HL073518
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2003
PERIOD OF PERFORMANCE END DATE: 12/31/2009

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PULSE CO-OXIMETER FOR MULTIPLE HEMOGLOBIN SPECIES - DESCRIPTION (provided by applicant): Conventional pulse oximetry has significant limitations because it works on the assumption that there are only two species of hemoglobin present in arterial blood, oxygenated hemoglobin (O2Hb) and reduced hemoglobin (RHb). In reality, two other hemoglobin species -- carboxyhemoglobin (COHb) and methemoglobin (metHb), collectively termed dyshemoglobins -- are present at all times. These two species of hemoglobin are formed endogenously at very low levels, but their quantities can increase to dangerous levels when carbon monoxide is present in inspired air or as a reaction to certain drugs or chemicals in the environment. All pulse oximeters used in medicine today, representing over 1,000,000 units worldwide, read oxygenation levels that are too high when there are elevated levels of dyshemoglobins in the blood. The alternative to pulse oximetry is to analyze arterial blood with a laboratory CO-oximeter. This procedure involves several different health care workers, potentially exposes personnel to blood borne pathogens, takes minutes or even hours to get results, and provides only a single data point in time. All of this adds cost, increases risks to health care workers, and delays appropriate treatment. Previous attempts by various companies to develop a noninvasive method of CO-oximetry have not succeeded. The limiting factors have been the correct selection of optical emitter wavelengths, spectral bandwidth of the emitters, and troublesome power instabilities of the requisite laser light sources. Kestrel Labs is developing a new oximeter that can use laser light sources for accurate photoplethysmographic measurements. This makes possible the world's first noninvasive and continuous four-analyte Pulse CO-Oximeter. It will provide clinicians with a powerful new tool for patient diagnosis and care. Kestrel Labs is addressing a major deficiency in pulse oximetry technology by developing a new type of oximeter that can simultaneously measure the four primary species of hemoglobin, including those that indicate whether a patient is suffering from carbon monoxide or certain forms of chemical poisoning. The only currently available option is to draw an arterial blood sample, send it to the hospital's blood lab, test it on an expensive blood analyzer, and wait until results are returned to the physician responsible for the patient's care. Kestrel Labs' new Pulse CO-Oximeter will provide accurate, continuous, and noninvasive measurements of these hemoglobin species, thereby avoiding additional costs, risks to health care workers, and delays to appropriate treatment. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2008	KESTREL LABS	3133 INDIAN ROAD	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	6	3/8/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $79,513 )
2009	2009	KESTREL LABS	3133 INDIAN ROAD	BOULDER	CO	80301	BOULDER	USA	Cardiovascular Diseases Research	001	6	9/17/2009	SUPPLEMENT FOR EXPANSION	$79,513
2009	2008	KESTREL LABS	3133 INDIAN ROAD	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	6	12/3/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $79,513

Issue Date FY: 2008 ( Subtotal = $998,972 )
2008	2008	KESTREL LABS	3131 INDIAN RD, SUITE K	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	6	7/30/2008	NON-COMPETING CONTINUATION	$998,972
														Subtotal = $998,972

Issue Date FY: 2007 ( Subtotal = $999,855 )
2007	2007	KESTREL LABS	3131 INDIAN RD, SUITE K	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	5	8/1/2007	NON-COMPETING CONTINUATION	$999,855
														Subtotal = $999,855

Issue Date FY: 2006 ( Subtotal = $923,835 )
2006	2006	KESTREL LABS	3131 INDIAN RD, SUITE K	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	4	7/28/2006	COMPETING CONTINUATION	$923,835
														Subtotal = $923,835

Issue Date FY: 2005 ( Subtotal = $279,577 )
2005	2005	KESTREL LABS	3131 INDIAN RD, SUITE K	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	3	11/25/2004	NON-COMPETING CONTINUATION	$279,577
														Subtotal = $279,577

Issue Date FY: 2004 ( Subtotal = $468,643 )
2004	2004	KESTREL LABS	3131 INDIAN RD, SUITE K	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	2	11/14/2003	EXTENSION WITH OR WITHOUT FUNDS	$468,643
														Subtotal = $468,643

Issue Date FY: 2003 ( Subtotal = $99,976 )
2003	2003	KESTREL LABS	3131 INDIAN RD, SUITE K	BOULDER	CO	80301	BOULDER	USA	Blood Diseases and Resources Research	000	1		NEW	$99,976
														Subtotal = $99,976

Grand Total All Awards = $3,850,371

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PULSE CO-OXIMETER FOR MULTIPLE HEMOGLOBIN SPECIES

Award Number: R44HL073518

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2003

PERIOD OF PERFORMANCE END DATE: 12/31/2009

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