Tuesday, July 1, 2025 7/1/2025

SONOTHROMBOLYSIS OF VASCULAR CLOTS WITH TARGETED BUBBLES

Award Number: R44HL071433
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2002
PERIOD OF PERFORMANCE END DATE: 12/31/2010

Group Awards By:

View Award Description

SONOTHROMBOLYSIS OF VASCULAR CLOTS WITH TARGETED BUBBLES - DESCRIPTION (provided by applicant): The long-term objective of this Phase II SBIR proposal is to develop targeted microbubbles in conjunction with ultrasound for the treatment of vascular thrombosis (Sonothrombolysis). Gas-filled microbubbles are currently used as vascular ultrasound diagnostic agents because of their exquisite ability to reflect sound. In addition, recent pre-clinical studies have demonstrated that ultrasound-mediated cavitation of microbubbles has utility in lysing platelet thrombi (clots). During the Phase I period, we have developed targeted microbubble agents and have demonstrated; 1) binding to thrombi in the mouse cremasteric artery model and 2) lysing thrombi in vitro more efficiently than non-targeted microbubbles. The research in the Phase II period of the grant will involve 5 parts: 1) synthesize bioconjugate ligands selective for the GP IIb/llla receptor on activated platelet thrombi, 2) develop microbubble formulations with shell membranes that possess efficient cavitational force for clot lysis, 3) undertake ultrasound physics studies to optimize cavitation of microbubbles for efficient ultrasound-mediated thrombolysis, 4) conduct preclinical studies in the occluded rabbit femoral artery model to determine safety and efficacy of targeted microbubbles and ultrasound using parameters based upon objectives 2) and 3), 5) perform pre-clinical studies in the left anterior descending (LAD) or left circumflex branch occlusion model in pigs examining safety and efficacy of ultrasound-mediated targeted microbubble thrombolysis therapy, and 6) perform CMC and stability studies. We hypothesize that ultrasound-mediated targeted microbubble therapies will offer efficient, less invasive, and safer alternatives to thrombolytic agents or emergency thrombectomies. Furthermore, ultrasound mediated therapies will provide affordable treatments that can be used in small hospitals and emergency rooms where expensive treatment is prohibitive.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2007	NUVOX PHARMA LLC	1635 EAST 18TH STREET	TUCSON	AZ	85715	PIMA	USA	Blood Diseases and Resources Research	002	5	6/15/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2010	2007	NUVOX PHARMA LLC	1635 EAST 18TH STREET	TUCSON	AZ	85715	PIMA	USA	Blood Diseases and Resources Research	001	5	12/9/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$178,273
2010	2007	IMARX THERAPEUTICS, INC	1635 EAST 18TH STREET	TUCSON	AZ	85719	PIMA	USA	Blood Diseases and Resources Research	000	4	11/17/2009	NON-COMPETING CONTINUATION	-$178,273
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	IMARX THERAPEUTICS, INC	1635 EAST 18TH STREET	TUCSON	AZ	85719	PIMA	USA	Blood Diseases and Resources Research	000	4	3/20/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $303,669 )
2007	2007	IMARX THERAPEUTICS, INC	1635 EAST 18TH STREET	TUCSON	AZ	85719	PIMA	USA	Blood Diseases and Resources Research	000	4	7/17/2007	NON-COMPETING CONTINUATION	$303,669
														Subtotal = $303,669

Issue Date FY: 2006 ( Subtotal = $402,876 )
2006	2006	IMARX THERAPEUTICS, INC	1635 EAST 18TH STREET	TUCSON	AZ	85719	PIMA	USA	Blood Diseases and Resources Research	000	3	6/28/2006	NON-COMPETING CONTINUATION	$402,876
														Subtotal = $402,876

Issue Date FY: 2005 ( Subtotal = $381,903 )
2005	2005	IMARX THERAPEUTICS, INC	1635 EAST 18TH STREET	TUCSON	AZ	85719	PIMA	USA	Blood Diseases and Resources Research	000	2	7/5/2005	COMPETING CONTINUATION	$381,903
														Subtotal = $381,903

Grand Total All Awards = $1,088,448

Top

All Categories

About

Search

Reports

Data Submission

Award Information

SONOTHROMBOLYSIS OF VASCULAR CLOTS WITH TARGETED BUBBLES

Award Number: R44HL071433

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2002

PERIOD OF PERFORMANCE END DATE: 12/31/2010

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer