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Dynamic single-cell analysis instrument to evaluate immune cell function

Award Number: R44GM149106
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Dynamic single-cell analysis instrument to evaluate immune cell function - The goal of this Fast-Track SBIR is to manufacture Chronos: a dedicated instrument for image- based dynamic, functional single-cell analysis for use with the CellChorus® TIMING™ (Time- Lapse Imaging Microscopy In Nanowell Grids) platform. The TIMING technological platform is also being validated by academic and commercial entities through peer-reviewed publications, presentations, and commercial contracts through the CellChorus Early Access Program, including new abstracts and publications by CellChorus and the lab from which we spun out. Importantly, a recent publication in Nature Cancer shows that TIMING can be used to identify the most potent cytolytic CAR T cells among populations of infusion products (Rezvan et al, Nat Cancer 2024). TIMING encompasses 1) plating cells in nanowells arrayed in grids of 5,000-10,000 nanowells; 2) rapid and gentle time-lapse imaging over hours with multiple light channels; and 3) AI-powered analysis of cell behaviors. This project addresses the second part of the platform (2) by creation of Chronos, an enclosed imager with the key features needed for users to very easily run TIMING assays without needing advanced microscopy training.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $519,196 )
2025	2025	CELLCHORUS INC	5000 GULF FWY RM 118	HOUSTON	TX	77204	HARRIS	USA	Biomedical Research and Research Training	003	3	7/21/2025	SUPPLEMENT FOR EXPANSION	$56,415
2025	2025	CELLCHORUS INC	5000 GULF FWY RM 118	HOUSTON	TX	77204	HARRIS	USA	Biomedical Research and Research Training	002	3	7/15/2025	NON-COMPETING CONTINUATION	$462,781
2025	2024	CELLCHORUS INC	5000 GULF FWY RM 118	HOUSTON	TX	77204	HARRIS	USA	Biomedical Research and Research Training	001	2	3/25/2025	EXTENSION WITH OR WITHOUT FUNDS	$216
2025	2023	CELLCHORUS INC	5000 GULF FWY RM 118	HOUSTON	TX	77204	HARRIS	USA	Biomedical Research and Research Training	000	1	3/25/2025	NEW	-$216
														Subtotal = $519,196

Issue Date FY: 2024 ( Subtotal = $1,483,544 )
2024	2024	CELLCHORUS INC	5000 GULF FWY RM 118	HOUSTON	TX	77204	HARRIS	USA	Biomedical Research and Research Training	000	2	7/11/2024	EXTENSION WITH OR WITHOUT FUNDS	$1,483,544
														Subtotal = $1,483,544

Issue Date FY: 2023 ( Subtotal = $324,340 )
2023	2023	CELLCHORUS INC.	5000 GULF FWY RM 118	HOUSTON	TX	77204	HARRIS	USA	Biomedical Research and Research Training	000	1	4/28/2023	NEW	$324,340
														Subtotal = $324,340

Grand Total All Awards = $2,327,080

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Dynamic single-cell analysis instrument to evaluate immune cell function

Award Number: R44GM149106

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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