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Functionally Closed Purification and Elution of Untouched Cells using Cleavable Magnetic Beads with Digital Magnetic Sorting

Award Number: R44GM149063
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Functionally Closed Purification and Elution of Untouched Cells using Cleavable Magnetic Beads with Digital Magnetic Sorting - Project Summary Isolation of specific and well-defined cell types to produce next generation cellular therapies remains a significant scale up and scale out challenge for autologous and allogeneic therapies. Through primary customer interviews of cell therapy developers, we learned there is an unmet need for scalable cell sorting systems that can isolate rare cell types on multiple markers in production of nuanced cellular therapeutics. With preliminary studies, we demonstrated that our scalable core technology (digital magnetic sorting) achieves superior rare cell isolation and can achieve parallelized multitarget sorting to address this need. In this proposal, we aim to develop a functionally closed, quantitative cell purification system that can isolate rare and specific cell types based on multiple markers at throughputs conducive for cell therapy manufacturing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	FERROLOGIX INC	23328 BARFIELD DR	VALENCIA	CA	91354	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	4/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,074,227 )
2024	2024	FERROLOGIX INC	23328 BARFIELD DR	VALENCIA	CA	91354	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	1/18/2024	NON-COMPETING CONTINUATION	$1,074,227
														Subtotal = $1,074,227

Issue Date FY: 2023 ( Subtotal = $921,412 )
2023	2023	FERROLOGIX INC	23328 BARFIELD DR	VALENCIA	CA	91354	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	2/1/2023	NEW	$921,412
														Subtotal = $921,412

Grand Total All Awards = $1,995,639

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Functionally Closed Purification and Elution of Untouched Cells using Cleavable Magnetic Beads with Digital Magnetic Sorting

Award Number: R44GM149063

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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