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A Uniquely Scalable Platform for Sequencing Tens of Millions of Single Cells from Complex Clinical Samples with a Streamlined Workflow

Award Number: R44GM149003
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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A Uniquely Scalable Platform for Sequencing Tens of Millions of Single Cells from Complex Clinical Samples with a Streamlined Workflow - PROJECT SUMMARY/ABSTRACT Single-cell sequencing (SC-seq) has revolutionized our understanding of cellular heterogeneity, gene expression, and disease mechanisms. However, its adoption in clinical and translational research remains limited due to throughput constraints, complex workflows, and sample preparation biases. Sansimeon is addressing these limitations by developing a high- throughput, streamlined platform for scalable single-cell sequencing. This innovative system integrates automated workflow for direct analysis of peripheral whole blood and dissociated tissue. Our goal is to deliver an end-to-end solution capable of processing large-scale single cell experiments, with applications in diagnostics, rare cell detection, drug discovery, and cancer therapy development. We leverage novel microfluidic technologies to achieve unmatched throughput and data fidelity while preserving cells’ native states. The project will validate this system in clinically relevant samples and optimize its computational tools to support scaled single- cell datasets. These efforts aim to advance clinical research and accelerate the adoption of single- cell sequencing in healthcare and drug development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $938,335 )
2025	2025	SANSIMEON INC	1209 N ORANGE ST	WILMINGTON	DE	19801	NEW CASTLE	USA	Biomedical Research and Research Training	000	2	8/8/2025	COMPETING CONTINUATION	$938,335
														Subtotal = $938,335

Grand Total All Awards = $938,335

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A Uniquely Scalable Platform for Sequencing Tens of Millions of Single Cells from Complex Clinical Samples with a Streamlined Workflow

Award Number: R44GM149003

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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