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Multi-omics profiling of individual exosomes for origin-tracing, biomarker discovery, and biological function characterization

Award Number: R44GM145015
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Multi-omics profiling of individual exosomes for origin-tracing, biomarker discovery, and biological function characterization - PROJECT SUMMARY / ABSTRACT Extracellular vesicles (EVs) exhibit high heterogeneity in biofluids, a feature that traditional bulk-level analysis approaches fail to capture in terms of individual variations. While various techniques exist for single-EV analysis, the majority focus primarily on surface proteins. Transcriptional analysis at the level of individual EVs, however, remains largely unexplored. To bridge this gap, we propose the development of a platform for multimodal digital profiling of individual EVs, leveraging next-generation sequencing and an optimized system for multiplex library preparation. This proposed platform will serve as a unique tool for high-throughput absolute quantification of single-EV genes and proteins. It aims to offer high-sensitivity, multi-dimensional biological insights, thereby potentially accelerating the advancement of EV-based diagnostics and targeted therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $861,162 )
2025	2025	WELLSIM BIOMEDICAL TECHNOLOGIES INC	160 E TASMAN DR	SAN JOSE	CA	95134	SANTA CLARA	USA	Biomedical Research and Research Training	001	3	6/13/2025	SUPPLEMENT FOR EXPANSION	$122,815
2025	2025	WELLSIM BIOMEDICAL TECHNOLOGIES INC	160 E TASMAN DR	SAN JOSE	CA	95134	SANTA CLARA	USA	Biomedical Research and Research Training	000	3	6/9/2025	NON-COMPETING CONTINUATION	$738,347
														Subtotal = $861,162

Issue Date FY: 2024 ( Subtotal = $801,485 )
2024	2024	WELLSIM BIOMEDICAL TECHNOLOGIES INC	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Biomedical Research and Research Training	000	2	7/25/2024	COMPETING CONTINUATION	$801,485
														Subtotal = $801,485

Grand Total All Awards = $1,662,647

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Multi-omics profiling of individual exosomes for origin-tracing, biomarker discovery, and biological function characterization

Award Number: R44GM145015

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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