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A Label-free Extracellular-vesicle Automated Purification System (LEAP System)

Award Number: R44GM144009
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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A Label-free Extracellular-vesicle Automated Purification System (LEAP System) - PROJECT SUMMARY / ABSTRACT Extracellular vesicles (EVs) are small lipid bilayer particles secreted by most cell types, which encapsulates biomolecules including lipids, proteins, and nucleic acids from cells of origin. Profiling of EV-derived biomarkers provides a promising approach for diagnosis of various diseases. However, one of the primary challenges for the research and application of EVs is a lack of a reliable method for efficient isolation of EVs and their subpopulations from complex biofluids. Researchers in this field suffer from tedious workflow, long processing time, high cost, and poor EV quality. To overcome the challenges, WellSIM proposes in this Phase II project, which built upon the promising results generated from our Phase I project, to complete development of a Label- free Extracellular-vesicle Automated Purification System (LEAP System) for isolation of total EVs or EV subpopulations from a variety of biofluids in a non-invasive and cost-effective manner. Once developed, the integrated LEAP System will offer excellent EV quality, throughput, and flexibility for EV isolation that can outperform ultracentrifugation and other isolation techniques.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	WELLSIM BIOMEDICAL TECHNOLOGIES INC	160 E TASMAN DR	SAN JOSE	CA	95134	SANTA CLARA	USA	Biomedical Research and Research Training	000	3	4/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $749,163 )
2023	2023	WELLSIM BIOMEDICAL TECHNOLOGIES INC	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Biomedical Research and Research Training	000	3	6/13/2023	NON-COMPETING CONTINUATION	$749,163
														Subtotal = $749,163

Issue Date FY: 2022 ( Subtotal = $749,646 )
2022	2022	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Biomedical Research and Research Training	000	2	6/16/2022	COMPETING CONTINUATION	$749,646
														Subtotal = $749,646

Grand Total All Awards = $1,498,809

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A Label-free Extracellular-vesicle Automated Purification System (LEAP System)

Award Number: R44GM144009

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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