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Object Oriented Data Analysis for Untargeted Metabolomics

Award Number: R44GM131487
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/11/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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Object Oriented Data Analysis for Untargeted Metabolomics - PROJECT SUMMARY/ABSTRACT In this Phase II SBIR application for Object Oriented Data Analysis for Untargeted Metabolomics, we propose to continue the research initiated in Phase I developing a software platform. In Phase I we showed functional Object Oriented Data Analysis (fOODA), which models raw RT x m/z x Ion Intensity data in functional form (12-14), can be applied to raw metabolomics data to automatically, and in an unbiased way, find peak differences across subject subgroups, and present the results to investigators in a clear way. The software runs fast (a few hours to process hundreds of sample files) in parallel on the AWS cloud. Requirements engineering through user discussions identified functions that will be added in Phase II (e.g., automate identification of isotopes, adducts, product ions, and ion suppression artifacts; link results to annotated databases; add analyses for dose response studies). The current software provides an initial architecture that will be further developed. Three aims are proposed: further develop statistical and annotation tools and validate them in simulations and 3 untargeted metabolomics studies (Aim 1); conduct extensive Requirements Engineering interviews with 100 metabolomics core directors, researchers, and clinicians (Aim 2); and write software to sell and install in core facilities (Aim 3). The first aim builds on the success of the Phase I project and is designed to optimize the analytic tools. The other two aims are focused on developing the commercial product. A new hire for each aim will be done to ensure we have the right skill set and expertise for these aims. The commercialization plan describes short- and long-term business development. In the short-term we will license proprietary software to metabolomics cores and offer statistical consulting services. In the long-term we will leverage our contacts with multi-omics cores to participate in BioRankings multi-omics platform where metabolomics, microbiome, and clinical data can be easily combined for translational statistical analysis. This will provide a second revenue stream for BioRankings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	WILLIAM D SHANNON CONSULTING LLC	1306 CULVERHILL DR	SAINT LOUIS	MO	63119	SAINT LOUIS	USA	Biomedical Research and Research Training	000	3	10/30/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $812,685 )
2021	2021	WILLIAM D SHANNON CONSULTING LLC	1306 CULVERHILL DR	SAINT LOUIS	MO	63119	SAINT LOUIS	USA	Biomedical Research and Research Training	000	3	4/27/2021	NON-COMPETING CONTINUATION	$812,685
														Subtotal = $812,685

Issue Date FY: 2020 ( Subtotal = $848,987 )
2020	2020	WILLIAM D SHANNON CONSULTING LLC	4041 FOREST PARK AVE STE 302	SAINT LOUIS	MO	63108	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	2	4/21/2020	COMPETING CONTINUATION	$848,987
														Subtotal = $848,987

Grand Total All Awards = $1,661,672

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Object Oriented Data Analysis for Untargeted Metabolomics

Award Number: R44GM131487

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/11/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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