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A high throughput, high resolution, and high sensitivity scanning X-ray fluorescence microprobe for elemental mapping in cell cultures and tissues for medical research and diagnosis

Award Number: R44GM112413
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2018

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A high throughput, high resolution, and high sensitivity scanning X-ray fluorescence microprobe for elemental mapping in cell cultures and tissues for medical research and diagnosis - ¿ DESCRIPTION (provided by applicant): Trace elements are well known to have critical roles in a wide variety of diseases, including cancer and neurodegenerative diseases such as Alzheimer's and Wilson's diseases. Due to their biological importance, there have been numerous studies performed with spectroscopy techniques such as laser ablation inductively coupled mass spectrometry (LA-ICP-MS) to understand absolute concentration values in tissue. More recent developments in synchrotron X-ray Fluorescence (XRF) have enabled rapid high resolution mapping of absolute concentration values, and, significantly, the quantitative distribution analysis of multiple trace elements at once. Such systems provide up to parts-per-billion sensitivity to map trace elements at micron- scale resolution in diseased tissue. We propose to develop a laboratory scanning X-ray fluorescence microprobe for the biomedical community that will make it possible for the first time to bring trace elemental mapping at the cellular level currently only achievable at synchrotron facilities. This will be achieved by bringig vast improvements to standard laboratory XRF by key innovations on the source, optics, and detector. Up to 4000X fluorescence signal gain over existing commercial micro-XRF systems will be achieved, enabling key capabilities for biomedical application x-ray fluorescence mapping within the laboratory. The proposed Phase II project aims to build a working prototype of the microXRF system. Key deliverables of this project include completing: system engineering design, final prototype of the x-ray source, prototype of Wolter x-ray mirror lens, integration of the system components, and experimental demonstration of ppm detection sensitivity at a spatial resolution of 10 m.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	000	3	11/20/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $740,687 )
2017	2017	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	000	3	6/20/2017	NON-COMPETING CONTINUATION	$740,687
														Subtotal = $740,687

Issue Date FY: 2016 ( Subtotal = $759,237 )
2016	2016	SIGRAY INC	151 ADAMS RANCH ROAD	WALNUT CREEK	CA	94595	CONTRA COSTA	USA	Biomedical Research and Research Training	000	2	6/29/2016	COMPETING CONTINUATION	$759,237
														Subtotal = $759,237

Grand Total All Awards = $1,499,924

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A high throughput, high resolution, and high sensitivity scanning X-ray fluorescence microprobe for elemental mapping in cell cultures and tissues for medical research and diagnosis

Award Number: R44GM112413

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2018

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