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High throughput laboratory X-ray illumination system for protein crystallography and screening

Award Number: R44GM112287
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/18/2015
PERIOD OF PERFORMANCE END DATE: 05/31/2019

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High throughput laboratory X-ray illumination system for protein crystallography and screening - Title: High performance, high throughput laboratory x-ray illumination system for protein crystallography Project Summary and Abstract X-ray protein crystallography is the leading method for determining the 3D structures of macromolecules (proteins, viruses, nucleic acids). Structural understanding provides key insight into their functionality and is now an essential tool for industrial applications in food & agriculture, protein engineering, and drug design. This has resulted in several high profile late-stage clinical drug trials for cancer and Alzheimer’s therapeutics. We propose to develop an X-ray illumination system comprising a proprietary x-ray source and x-ray optic optimized for the Single-Wavelength Anomalous Dispersion (SAD) approach to x-ray crystallography. This illumination beam system is designed to deliver x-ray energies that optimize the signal of commonly used scatterers in the SAD technique, and will furthermore provide 8X higher flux than current state-of-the-art laboratory x-ray sources. The key innovations include a novel pattern and new materials for the x-ray source targets and an axially symmetric x-ray optical train that provides a small crossfire for the illumination beam. This proposed phase II project will result in the development of a prototype of the illumination beam system and experimental demonstration of the intended specifications and parameters.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	000	3	11/16/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $671,418 )
2017	2017	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	000	3	8/16/2017	NON-COMPETING CONTINUATION	$671,418
														Subtotal = $671,418

Issue Date FY: 2016 ( Subtotal = $825,315 )
2016	2016	SIGRAY INC	151 ADAMS RANCH ROAD	WALNUT CREEK	CA	94595	CONTRA COSTA	USA	Biomedical Research and Research Training	000	2	8/24/2016	COMPETING CONTINUATION	$825,315
														Subtotal = $825,315

Grand Total All Awards = $1,496,733

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High throughput laboratory X-ray illumination system for protein crystallography and screening

Award Number: R44GM112287

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/18/2015

PERIOD OF PERFORMANCE END DATE: 05/31/2019

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