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PORTABLE LAB-ON-A-CHIP FLOW CYTOMETER: PROTOTYPE AND APPLICATION DEVELOPMENT

Award Number: R44GM103677
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2010
PERIOD OF PERFORMANCE END DATE: 04/30/2014

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PORTABLE LAB-ON-A-CHIP FLOW CYTOMETER: PROTOTYPE AND APPLICATION DEVELOPMENT - DESCRIPTION (provided by applicant): Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development NanoSort RESEARCH & RELATED Other Project Information 7. PROJECT SUMMARY The lab-on-a-chip NanoSort device proposed here advances the achievements of the Phase I Beta Prototype project. This device will be appropriate for commercial success by improving access to and reducing the cost and complexity of sorting flow cytometry. Furthermore, it will expand the applications that this device can serve, including translational and clinical point-of-care flow cytometry applications for diagnostics, prognosis, and personalized medicine. Having completed key milestones in the Phase I program, such as mas- producible injection molded chips, advanced signal detection and processing and key performance metrics, we propose to extend the capabilities to compete with best-in-class devices. Our Aims for this project are to create a device (NanoSort-1 or NS-1) that will have improved performance parameters of 6-color detection with a single photomultiplier tube (PMT), 4-way sorting using low shear stress piezoelectric (PZT) actuators, and a robust digital signal processing algorithm (Color-Space-Time (CoST) implementation that allows 10,000 events per second detection and sorting. In addition to these innovations, we will construct the device using current good manufacturing processes (cGMP) to assure that this device will be UL and CE certified and scalable to 10,000 units per year. We will validate this device with consultation from established researchers at UCSD and device manufactures (Becton-Dickinson and Life Technologies).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $523,872 )
2013	2013	NANOSORT INC	7770 REGENTS ROAD	SAN DIEGO	CA	92122	SAN DIEGO	USA	Biomedical Research and Research Training	000	3	7/12/2013	NON-COMPETING CONTINUATION	$473,592
2013	2013	NANOSORT INC	7770 REGENTS ROAD	SAN DIEGO	CA	92122	SAN DIEGO	USA	Biomedical Research and Research Training	001	3	7/24/2013	SUPPLEMENT FOR EXPANSION	$50,280
														Subtotal = $523,872

Issue Date FY: 2012 ( Subtotal = $498,607 )
2012	2012	NANOSORT INC	7770 REGENTS ROAD	SAN DIEGO	CA	92122	SAN DIEGO	USA	Biomedical Research and Research Training	000	2	4/27/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$498,607
														Subtotal = $498,607

Grand Total All Awards = $1,022,479

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PORTABLE LAB-ON-A-CHIP FLOW CYTOMETER: PROTOTYPE AND APPLICATION DEVELOPMENT

Award Number: R44GM103677

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2010

PERIOD OF PERFORMANCE END DATE: 04/30/2014

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