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A low-cost instrument for nucleic acid isolation.

Award Number: R44GM103053
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2012
PERIOD OF PERFORMANCE END DATE: 01/31/2018

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A low-cost instrument for nucleic acid isolation. - ¿ DESCRIPTION (provided by applicant): Sample preparation frequently presents a bottleneck for clinical molecular biology workflows and diagnostic tests. Whereas there are many molecular detection modalities, there are only a handful of automated sample preparation workflow strategies. Existing instruments that are built around these sample preparation strategies and chemistries range in cost from $17-$150k, and yet they still do not include an integrated method for lysing difficult-to-disrupt organisms such as gram-positive bacteria or the acid fast bacilli (.e., Mycobacterium). To address these limitations, we will integrate Akonni's sample preparation technologies into a low-cost automated instrument that can process a variety of sample types with simple-to-use consumable kits. Based on Phase 1 results, the two-year goal for Phase 2 is to demonstrate the efficacy of pre-production integrated sample preparation systems with a disposable M. tuberculosis/sputum DNA extraction kit in a targeted intended use setting - a clinic with a moderate to high TB burden rate.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	AKONNI BIOSYSTEMS INC.	400 SAGNER AVE STE 300	FREDERICK	MD	21701	FREDERICK	USA	Biomedical Research and Research Training	000	3	7/12/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $736,083 )
2016	2016	AKONNI BIOSYSTEMS INC	9702 WOODFIELD COURT	NEW MARKET	MD	21774	FREDERICK	USA	Biomedical Research and Research Training	000	3	7/18/2016	NON-COMPETING CONTINUATION	$736,083
														Subtotal = $736,083

Issue Date FY: 2015 ( Subtotal = $761,218 )
2015	2015	AKONNI BIOSYSTEMS INC	9702 WOODFIELD COURT	NEW MARKET	MD	21774	FREDERICK	USA	Biomedical Research and Research Training	000	2	7/27/2015	COMPETING CONTINUATION	$761,218
														Subtotal = $761,218

Grand Total All Awards = $1,497,301

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A low-cost instrument for nucleic acid isolation.

Award Number: R44GM103053

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2012

PERIOD OF PERFORMANCE END DATE: 01/31/2018

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